Project Grant K99HD120644
- The National Institute of Child Health and Human Development awarded California Institute of Technology $100,228 on December 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct research identifying molecular and structural cues introduced at fertilization that influence early cell fate biases in the mammalian embryo. The research traces how sperm-derived components and the second polar body establish asymmetries as early as the 2-cell stage,...
- The National Institute of Child Health and Human Development awarded the University of California, Santa Barbara $123,957 on September 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) for research into how mechanical forces coordinate cell movements during vertebrate gastrulation, specifically examining the Spemann-Mangold organizer's role in establishing germ layers and embryonic axes. The funded research develops and applies...
- The National Institute of Child Health and Human Development awarded California Institute of Technology $128,331 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate neural crest regeneration and its role in reducing the severity of congenital birth defects. The research tests the hypothesis that cranial and cardiac neural crest forming regions can regenerate during a critical developmental period to rescue migratory neural...
- The National Institute of Child Health and Human Development awarded $430,375 to the University of California Santa Cruz on August 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) to investigate the role of RNA-modifying enzymes in regulating totipotent gene expression during early embryonic development. The research explores how the putative RNA methyltransferase METTL7A1 regulates zygotic genome activation and totipotency in mouse...
- The National Institute of Child Health and Human Development awarded the University of California, San Diego $153,560 on December 1, 2026, under the Child Health and Human Development Extramural Research Program (CFDA 93.865) to investigate gene regulatory mechanisms driving totipotency induction in human stem cells. The research examines how RNA splicing dysfunction alters early human development through integrative transcriptomic, epigenomic, and proteomic profiling. The work focuses on...
- The National Institute of Child Health and Human Development awarded The Trustees of Princeton University $315,664 on January 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate how amniotic fluid pressure and composition regulate branching morphogenesis across embryonic organs. The research tests the hypothesis that amniotic fluid couples the rate of branching morphogenesis in organs throughout the embryo, with particular focus on...
- The National Institute of Child Health and Human Development awarded $668,485 to the University of California, San Diego on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate DNA repair mechanisms in hypoxia-induced placental genomic instability. The research examines increased genomic instability in placental villous tissue and trophoblast stem cells associated with maternal vascular malperfusion, a pattern of placental...
- The National Institute of Child Health and Human Development awarded Duke University $581,258 on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate transposable elements as mechano-response enhancer elements regulating human embryonic stem cell fate. The research examines how mechanical forces regulate transposable element sequences that control gene expression and pluripotent stem cell differentiation. The project tests three...
- The National Institute of Child Health and Human Development, part of the Department of Health and Human Services National Institutes of Health, awarded $456,500 to The University of Texas Southwestern Medical Center on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award funds molecular characterization of human pregnancy-induced cervical epithelium through two research aims. First, the recipient will apply single-cell and spatial...
- The National Institute of Child Health and Human Development awarded The Trustees of Columbia University in the City of New York $444,824 on August 20, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to engineer human pluripotent stem cell (HPSC)-derived endometrial organoids for modeling regeneration and disease mechanisms. The project will develop an innovative platform that recapitulates physiological interactions and developmental trajectories...
The National Institute of Child Health and Human Development awarded California Institute of Technology $128,331 on September 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) to investigate the hydraulic regulation of human gastrulation and mesodermal patterning using stem cells. The research employs a novel three-dimensional stem cell-based model termed "lumenoids" to dissect mechanobiological principles underlying early embryogenesis. The work addresses how fluid pressure in the amniotic cavity, cortical tension, and geometric constraints influence mesoderm induction and patterning—processes poorly understood due to ethical and technical limitations in studying human embryos directly. The study integrates biophysical measurements, live imaging, spatial transcriptomics, and genetic perturbations across three key aims: elucidating how pressure influences mesoderm induction; identifying pressure effects on mesodermal gene regulatory networks; and exploring mechanotransduction pathways and the role of extra-embryonic hypoblast tissue in shaping mesodermal patterning. Findings are intended to advance regenerative medicine strategies for directed stem cell differentiation and provide insights into early pregnancy loss, which accounts for up to 50% of pregnancies failing within the first few weeks due to developmental errors. Performance occurs in Pasadena, California, with a period of performance from September 1, 2026, through August 31, 2028. This is a project grant, the assistance type for individual research project awards under the NIH structure.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $128.3k | 8/21/26 |