Project Grant R21HD117517
- The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded a $133,401 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the Fred Hutchinson Cancer Center, located in Seattle, WA. The grant, awarded on September 1, 2025, is intended to develop computational models that can identify the sequence of changes a cell undergoes during differentiation and maturation, and compare changes in gene expression...
- The National Institute of Child Health and Human Development (NICHD) awarded Yale University a $921,250 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant funds a 2-year project to define the molecular pathways governing chromocenter restructuring before and after fertilization. The study aims to determine how the chromatin regulator DOT1L controls chromocenter disassembly during sperm nuclear condensation, as well as how DOT1L...
- The National Institute of Child Health and Human Development (NICHD) awarded a $411,125 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to Syracuse University to develop a microfluidic human placenta organoid model. The goal is to generate human trophoblast stem cells (HTSCs) from induced pluripotent stem cells and use them to create a placenta organoid system that can replicate early/mid-gestation placental development. The researchers will study the role of...
- This Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) provides $113,073 to Temple University to investigate the role of the YAP1 protein in the specification of blood cell precursors during embryonic development. The central hypothesis is that YAP1 mediates the recruitment of the EZH2 chromatin regulator to suppress blood lineage genes during the formation of hemangioblasts, which are...
- This $156,500 Project Grant was awarded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), to the University of Hawaii at Manoa. The objective is to create an in vitro 3D model of the human yolk sac using human pluripotent stem cells, with the goal of studying the impact of environmental and genetic factors on this critical embryonic structure. The project will...
- This federal Project Grant award, funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), is supporting research on the role of decidual extracellular vesicles in mediating placental insufficiency. The $654,671 award, which commenced on August 1, 2025 and is scheduled for completion by April 30, 2030, is being conducted by the awardee, Yale University. The key...
- This $163,145 Project Grant awarded on August 7, 2025 by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research Program (CFDA 93.865), aims to address critical questions pertaining to impaired placentation associated with fetal growth restriction (FGR). The principal investigator, a pediatric and fetal surgeon, will use this 5-year award to develop unique cross-disciplinary skills and...
- This federal Project Grant award, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to understand the mechanism of pluripotency transitions during peri-implantation development. The $760,617 award to The Children's Hospital Corporation, doing business as Boston Children's Hospital, aims to address the technical challenges in working with limited...
- This $616,841 project grant was awarded by the National Institute of Child Health and Human Development (NICHD), under the CFDA program "Child Health and Human Development Extramural Research", to Yale University beginning on August 15, 2025 and scheduled for completion on April 30, 2030. The project aims to investigate the molecular mechanisms that regulate genome activation and gene expression during embryonic development in vertebrates, with a focus on understanding how specific...
- The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded a $606,518 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the Magee-Womens Research Institute and Foundation. The grant, awarded on June 5, 2025, supports research to develop and test the safety and feasibility of spermatogonial stem cell (SSC) transplantation and testicular tissue grafting techniques for restoring fertility in patients,...
The National Institute of Child Health and Human Development (NICHD), under its Child Health and Human Development Extramural Research program (CFDA 93.865), awarded a $460,625 project grant to Yale University to fund research on the mechanisms of hematopoietic stem cell development during fetal life. The 2-year project, awarded on August 11, 2025, with an ultimate completion date of July 31, 2027, aims to investigate the endothelial-to-hematopoietic transition process that produces multipotent erythro-myeloid progenitors and leads to the emergence of hematopoietic stem cells in the fetal liver during early mouse development. The research will focus on identifying the signals that promote hematopoietic stem cell expansion in the fetal liver while balancing the pro-differentiation effects of stem cell factor and thrombopoietin receptor signaling.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $460.6k | 8/7/25 |