Project Grant R21HD118352
- The National Institute of Child Health and Human Development awarded Beth Israel Deaconess Medical Center $724,852 on September 1, 2026, under CFDA 93.865 (Child Health and Human Development Extramural Research) to investigate lymphatic pathology caused by dysregulated NFATC1 signaling using Down syndrome as a model. The research will examine how increased dosage of chromosome 21 genes DYRK1A and DSCR1 drives NFATC1 hyperphosphorylation and functional suppression, disrupting lymphatic...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded $845,935 to the Research Institute At Nationwide Children's Hospital on July 21, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to establish a single-cell and spatial atlas of trisomy 21 hearts using both Down syndrome mouse models and patient-specific induced pluripotent stem cells. The award funds research aimed at elucidating cellular and tissue mechanisms of septal...
- The National Institutes of Health Office of the Director awarded the University of Southern California $462,951 on July 15, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to measure real-world stepping and walking performance in infants and toddlers with Down syndrome. The award funds validation of accelerometer-based wearable step-counting devices for infants with Down syndrome, addressing a gap in clinical measurement tools. The project will establish the accuracy of step...
- The National Institutes of Health Office of the Director awarded Wake Forest University Health Sciences $417,450 under the Trans-NIH Research Support program (CFDA 93.310) on September 1, 2026, to conduct computational phenotyping research aimed at identifying early indicators of Down Syndrome Regression Disorder and detecting at-risk patients. The research will leverage electronic health records from over 12 million patients served by Advocate Health to develop artificial intelligence-driven...
- The Children's Hospital of Philadelphia Research Institute received a $289,158 Project Grant awarded on September 15, 2025, under the National Heart, Lung, and Blood Institute's Cardiovascular Diseases Research program (CFDA 93.837) to conduct the CASCADE (Cardiometabolic Risk and Comorbidities in Adults with Down Syndrome—Electronic Health Record Examination) study. This research initiative will deliver a comprehensive epidemiological analysis of cardiometabolic risk factors in adults with Down...
- The National Institute of Child Health and Human Development awarded Trustees of Boston University $131,694 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to characterize neural correlates of motor skill development in children with Down syndrome. The research uses upper extremity reaching as a model motor behavior to identify associations between reaching kinematics and brain activity in two pediatric cohorts. During the two-year...
- The National Institutes of Health Office of the Director awarded the University of New Mexico Health Sciences Center $419,375 on July 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to investigate mechanisms of vascular dysfunction in Down syndrome. The research examines endothelial dysfunction and glycocalyx depletion in a mouse model of Down syndrome (TCMAC21 mice) to understand cardiovascular disease risk in the Down syndrome population. The study investigates how...
- The National Institute of Child Health and Human Development awarded the University of Connecticut Health Center $457,875 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to develop and deploy an inducible gene dosage correction system in Down syndrome organoid and rodent models carrying human chromosome 21. The research uses an XIST-based transgene system to reversibly silence one copy of chromosome 21 across multiple cell types,...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded the University of Wisconsin System $568,615 on September 2, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to investigate the molecular mechanisms underlying synaptic deficiency in Down syndrome. The research project, titled "Molecular Mechanisms Underlying Synaptic Deficiency in Down Syndrome" (R01HD120347), will use isogenic trisomy 21 disorder-specific human...
- The National Institute of Child Health and Human Development awarded The Johns Hopkins University $297,252 on September 21, 2025, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the impact of chromosome 21 dosage on the placenta secretome and neurodevelopment in Down syndrome. The research examines whether placental abnormalities contribute to altered cortical development in individuals with Down syndrome (trisomy 21). The project uses...
The National Institutes of Health Office of the Director awarded Ann & Robert H Lurie Children's Hospital of Chicago $448,860 on August 21, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to co-design a digital care pathway that improves primary care clinician adherence to pediatric Down syndrome health supervision guidelines. The project will develop a scalable digital pathway to facilitate clinician implementation of evidence-based Down syndrome screening, early treatment, and behavioral counseling recommendations across different primary care settings—academic practices, community practices, and federally qualified health centers—and across different electronic health record platforms. Over a two-year period, the award will support a multiphase developmental approach. Aim 1 uses pre-implementation focus groups with adolescents with Down syndrome, family caregivers, clinicians, and organizational leaders to identify implementation determinants, strategies, and digital requirements informed by the Consolidated Framework for Implementation Research and its accompanying Expert Recommendations for Implementing Change tool. The project will also establish a longitudinal data capture structure within a learning health system to support future research on children with Down syndrome. Work is performed in Chicago, Illinois. The period of performance runs from August 21, 2026, through July 31, 2028. As a Project Grant (R21), the award supports exploratory and developmental research with scientific merit review and program relevance assessment by a national advisory council.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $448.9k | 8/21/26 |