Project Grant R21HD116135
- This $160,000 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under CFDA Program 93.865 - Child Health and Human Development Extramural Research supports research to understand fetal liver lipid metabolism under intrauterine growth restriction (IUGR) using a novel preeclampsia mouse model. The research aims to investigate the mechanisms linking IUGR to the development of adult non-alcoholic fatty liver disease (NAFLD), with a focus on the role of...
- This $163,145 Project Grant awarded on August 7, 2025 by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research Program (CFDA 93.865), aims to address critical questions pertaining to impaired placentation associated with fetal growth restriction (FGR). The principal investigator, a pediatric and fetal surgeon, will use this 5-year award to develop unique cross-disciplinary skills and...
- The National Institute of Child Health and Human Development (NICHD) awarded a $411,125 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to Syracuse University to develop a microfluidic human placenta organoid model. The goal is to generate human trophoblast stem cells (HTSCs) from induced pluripotent stem cells and use them to create a placenta organoid system that can replicate early/mid-gestation placental development. The researchers will study the role of...
- The National Institutes of Health (NIH) awarded a Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to New York University (NYU) School of Medicine in the amount of $1,525,500 on September 10, 2025. The grant will support a research project titled "Small Intestinal Remodeling Across Pregnancy Cycles" over the period of September 10, 2025 to August 31, 2028. The goal of the project is to identify the cellular, molecular, and tissue-level mechanisms that remodel...
- The National Institute of Child Health and Human Development (NICHD) awarded a $161,000 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to The Research Foundation for the State University of New York (RF SUNY). The grant, awarded on July 23, 2024, will support research to identify the hepatic epigenomic adaptations to excessive early-life cholesterol exposure due to maternal hypercholesterolemia, and evaluate the efficacy of maternal...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to investigate how amniotic fluid pressure and composition affect branching morphogenesis across organs during embryonic development. The $156,104 award, with a performance period from January 1, 2026 to July 31, 2028, will fund quantitative imaging analysis to compare...
- This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $485,925 to the University of Massachusetts Boston to develop novel antioxidant compounds for treating preeclampsia, a life-threatening pregnancy complication. The primary goal is to design and synthesize cationic hydrazone antioxidants that can target mitochondria to reduce oxidative stress, improve...
- The U.S. National Institute of Child Health and Human Development (NICHD) awarded a $766,982 Project Grant to Carnegie Mellon University under the Child Health and Human Development Extramural Research program (CFDA 93.865). The project aims to develop and validate a novel computational framework to simulate uteroplacental hemodynamics and placentation, with the goal of identifying metrics for early detection of pregnancy complications related to abnormal placental formation. This research...
- This Project Grant award, valued at $643,049.00, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports the development of a physiomimetic model of endometrioma, a type of endometriotic lesion, to study processes driving lesion initiation, ovarian stroma invasion, and persistence in a chronic inflammatory environment. The research aims to uncover...
- This federal Project Grant award, funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), is supporting research on the role of decidual extracellular vesicles in mediating placental insufficiency. The $654,671 award, which commenced on August 1, 2025 and is scheduled for completion by April 30, 2030, is being conducted by the awardee, Yale University. The key...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is focused on engineering in vitro models of pregnancy-induced liver changes. The goal is to develop and utilize liver microtissues containing primary mouse liver cells to elucidate the role of paracrine factors and in vivo preconditioning on phenotypic changes in the liver during pregnancy. The $440,908 award, with a project period from Sep 1, 2025 to Aug 31, 2027, will support the fabrication of non-pregnant mouse liver microtissues using multiple primary liver cell types and liver decellularized extracellular matrix. These microtissues will be compared to those derived from pregnant mouse livers to better understand pregnancy-induced alterations in liver physiology, including changes in organ size, insulin sensitivity, protein/metabolite levels, and drug metabolism enzymes. This research aims to address knowledge gaps regarding population-specific dosing information for medications used in obstetrics patients.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $440.9k | 8/29/25 |