This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 - Child Health and Human Development Extramural Research program will support a $731,893 research project to characterize the epigenomic mechanisms underlying endometriosis severity. The primary grantee, The University of Texas Health Science Center at San Antonio, will perform large-scale single-cell epigenomic profiling, allele-specific gene regulation analysis, and develop...
This federal Project Grant award, funded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to investigate the impact of obesity and adiposity on the human endometrium. The $195,000 award, with a performance period from August 1, 2024 to July 31, 2026, will support three key research activities:
Single-nucleus RNA sequencing to comprehensively understand how pathologic adiposity...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is supporting the development of a novel, noninvasive approach for early detection of endometriosis. The $173,536 award, spanning August 2024 to August 2026, is being provided to a collaborative partnership between Henry Ford Health and Michigan State University Health Sciences.
The project aims to harness...
This federal Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) will provide $233,250 from April 1, 2025 to March 31, 2027 to The Washington University in Missouri. The goal of the research is to identify the central and peripheral mechanisms underlying endometriosis pain and changes in pain after lesion removal surgery. Key activities include:
Characterizing pain, endometriosis...
This $179,564 federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) aims to enhance understanding of human-specific mechanisms governing embryonic development during the critical implantation stage. The principal investigator at Yale University will use novel 3D stem cell-based models to identify the biomechanical effects of Wnt/β-catenin signaling on human...
The National Institute of Child Health and Human Development awarded a $232,308 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to the Magee-Womens Research Institute and Foundation in Pittsburgh, PA. The grant will support research to elucidate the role of the hyaluronan extracellular matrix in regulating the establishment and maintenance of the ovarian reserve, which is critical for female reproductive longevity. The research will investigate how changes...
This federal Project Grant award of $490,699 from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) supports research to characterize the key immune pathways that interact with hormonal responses in endometriosis. The research will utilize large-scale population genetics studies and single-cell multi-omic profiling to nominate shared risk genes between endometriosis and inflammatory conditions. A key focus is on validating the role of the IL-1 signaling...
This $411,125 Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports an exploratory study to generate a microfluidic human placenta model using human trophoblast stem cells derived from induced pluripotent stem cells.
The key products and services to be delivered through this high-risk, high-reward research include: 1) developing methods to derive human...
This federal Project Grant award of $495,181.00 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to elucidate the cellular and molecular mechanisms underlying placenta accreta, a serious maternal condition characterized by excessive placental invasion into the uterus.
The research aims to investigate how scarring and dysregulation of the uterine microenvironment...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $309,251 to Expanse Bio LLC to develop an ex vivo microfluidic organ perfusion device for long-term culture and assessment of whole ovaries. The goal is to create a more physiologically relevant model for evaluating the ovotoxicity (ovarian damage) potential of drug candidates, particularly...