Project Grant DP2HL185101
- This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is focused on engineering in vitro models of pregnancy-induced liver changes. The goal is to develop and utilize liver microtissues containing primary mouse liver cells to elucidate the role of paracrine factors and in vivo preconditioning on phenotypic changes in the liver during pregnancy. The $440,908 award,...
- This $2,970,076 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to investigate the developmental programming of adult intestinal stem cells (ISCs) and how an obesogenic maternal environment during pre- and postnatal development can establish a maladaptive pre-pathological ground state in offspring. Using genetically engineered mouse and organoid models, the...
- This Project Grant award of $226,608.00 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) is funding research to identify the mechanistic link between fetal glucagon and placental nutrient delivery. The goal is to establish how fetal glucagon regulates placental lactogen secretion and uterine blood flow as an adaptive mechanism for matching nutrient supply to...
- This $249,000 Project Grant was awarded by the National Institute of Child Health and Human Development (NICHD), a division of the U.S. Department of Health and Human Services, under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports research at the University of Florida focused on in utero interventions to prevent adverse metabolic health outcomes, including non-communicable diseases like cardiovascular disease, hypertension, and type 2...
- The U.S. National Institute of Child Health and Human Development (NICHD) awarded a $766,982 Project Grant to Carnegie Mellon University under the Child Health and Human Development Extramural Research program (CFDA 93.865). The project aims to develop and validate a novel computational framework to simulate uteroplacental hemodynamics and placentation, with the goal of identifying metrics for early detection of pregnancy complications related to abnormal placental formation. This research...
- The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded a $161,735 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the Metis Foundation, a non-profit research organization based in San Antonio, Texas. The funding will support a pilot feasibility study on a single-session, CBT-informed treatment for loss-of-control eating during pregnancy. The goal is to develop a brief, evidence-based intervention...
- This $521,829 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The funding supports a research project titled "Liver PRLR Signaling in Metabolic Adaptation to Pregnancy" conducted by the University of Pittsburgh. The project aims to characterize the role of liver-specific prolactin receptor (PRLR) signaling in regulating...
- This $163,145 Project Grant awarded on August 7, 2025 by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research Program (CFDA 93.865), aims to address critical questions pertaining to impaired placentation associated with fetal growth restriction (FGR). The principal investigator, a pediatric and fetal surgeon, will use this 5-year award to develop unique cross-disciplinary skills and...
- This $448,441 federal Project Grant awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will support research at Emory University to investigate the role of mediobasal hypothalamic gliosis in gestational weight gain and visceral fat accretion. The primary aim is to provide foundational data on a potential neural mechanism underlying dysregulated or pathological weight gain during...
- This Project Grant award, valued at $643,049.00, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports the development of a physiomimetic model of endometrioma, a type of endometriotic lesion, to study processes driving lesion initiation, ovarian stroma invasion, and persistence in a chronic inflammatory environment. The research aims to uncover...
The National Institutes of Health (NIH) awarded a Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to New York University (NYU) School of Medicine in the amount of $1,525,500 on September 10, 2025. The grant will support a research project titled "Small Intestinal Remodeling Across Pregnancy Cycles" over the period of September 10, 2025 to August 31, 2028. The goal of the project is to identify the cellular, molecular, and tissue-level mechanisms that remodel the small intestine during pregnancy to support the massive increase in nutrient uptake required. This research aims to provide foundational insights into the biology underlying pregnancy-associated diseases like cardiovascular disease, diabetes, and metabolic disorders, which are leading causes of maternal morbidity and mortality. The project will leverage NYU's expertise in epithelial tissue regeneration and nutrient metabolism to establish a mechanistic understanding of the programs that remodel maternal digestive organs during pregnancy.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.5m | 9/8/25 |