This National Institute of Child Health and Human Development (NICHD) Project Grant award, under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $262,808 to Beth Israel Deaconess Medical Center (Bidmc) to develop and test water-soluble prodrugs of the compound AKT-1005 for the treatment of preeclampsia. The key products and services to be delivered through this funding include: Synthesizing, screening, and evaluating the solubility, stability, and in...
This Project Grant award from the Department of Health and Human Services National Institutes of Health National Institute of Child Health and Human Development provides $769,916 to Emergent Biotechnologies LLC for research into a novel therapy for preeclampsia. The funding supports Phase 1 of developing and characterizing a handle region peptide as an innovative treatment for preeclampsia under the Child Health and Human Development Extramural Research program (CFDA 93.865). Phase 1 work will...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $1,435,204 to the University of Texas Medical Branch at Galveston (UTMB) from June 1, 2024 to March 31, 2029. The funding supports research to assess the efficacy of the non-mammalian disaccharides trehalose and lactotrehalose in preventing and treating preeclampsia, a leading cause of maternal and fetal...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $456,251 to Colorado State University (CSU) to investigate the role of maternal obesity and inflammation in the development of preeclampsia and its long-term impacts on offspring cardiometabolic health. The overarching goal is to test the hypothesis that pro-inflammatory factors produced by maternal...
This federal Project Grant award of $234,000.00 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) aims to investigate the functional importance of a novel NF-kB genetic variant (rs230511) in preeclampsia. The grant will combine human physiological studies with CRISPR-Cas9 gene editing to explore how this variant influences inflammatory responses and impairs uteroplacental vascular...
The federal Project Grant award R01HD112930, totaling $632,110, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports research aimed at "Reducing the Risk of Chronic Hypertension and Improving Vascular Function Following Preeclampsia", a major public health issue accounting for significant maternal complications and long-term cardiovascular disease...
The National Institute of Child Health and Human Development awarded a $293,756 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to the Institute for Systems Biology to conduct research on understanding the molecular mechanisms associated with common obstetric disorders like preeclampsia, preterm birth, and fetal growth restriction. The project aims to leverage placental multiomics data, including metabolomic, proteomic, and transcriptomic analyses, to...
The National Institute of Child Health and Human Development (NICHD) awarded a $250,500 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to Cedars-Sinai Medical Center in West Hollywood, CA. The grant, titled "Impaired Renal Reserve and Preeclampsia," runs from August 1, 2024 to July 31, 2026. The project will use state-of-the-art methods, including in vivo plasma volume measurements, uterine artery blood flow measurements, preeclampsia biomarkers,...
The University of Texas at Austin was awarded a $191,965 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant's objective is to identify and functionally validate transcription factors that drive preeclampsia-specific gene expression programs, and to understand the regulatory mechanisms of these factors, using human trophoblast stem cells as a model system....
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will fund research on the neuroprotective actions of the apelinergic axis in the long-term cerebrovascular consequences of preeclampsia. The award of $232,500 was made on August 13, 2024 to Wake Forest University Health Sciences, a private, non-profit academic medical center. The research will utilize...