Project Grant R21HD116028

Award Date 8/5/24
Completion Date 7/31/26
Dollars Obligated $214K
Federal Grant Program
93.865
Assistance Type
Project Grant
Place of Performance
Austin, TX 78759, USA
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This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $213,945 to the University of Texas at Austin to develop an in vitro human spinal neural tube model for studying the genetic and environmental factors contributing to spina bifida.

The key objectives are to:

  1. Utilize human induced pluripotent stem cells to create 3D spinal neural tube organoids as a human-relevant model for spina bifida.
  2. Develop a spinal neural tube-on-a-chip model to better recapitulate the in vivo spatiotemporal microenvironment and study how genetic modifications (e.g. GPR161) and teratogens affect neural tube formation.
  3. Enhance scientific understanding of gene-environment interactions on human spinal neural tube development and advance in vitro modeling of the human spinal neural tube system.

The 2-year project runs from August 2024 to July 2026 and aims to address current gaps in modeling human neural tube defects like spina bifida.

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