This Project Grant award of $449,391.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research at the University of Florida to develop combinatorial approaches to enhance breathing recovery after cervical spinal cord injury. The goal is to maximize breathing recovery by pairing therapeutic acute intermittent hypoxia with distinct respiratory training paradigms,...
This Project Grant award from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) provides $4,182,053.00 to The Spaulding Rehabilitation Hospital Corporation to conduct a clinical trial titled "Breathing Low Oxygen to Enhance Spinal Stimulation Training and Functional Recovery for Aging Adults with Chronic SCI: The BO2ST-II Trial." The award period runs from Sep 30, 2024 to Sep 29, 2028. The project will investigate using low-oxygen...
The federal Project Grant award R21HD116006 for $270,000.00, awarded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), will fund research to elucidate the cellular and molecular mechanisms enabling spinal cord regeneration in zebrafish. The primary objectives are to: 1) Analyze cell state changes over time associated with successful versus failed spinal cord...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is providing $330,000 to the Rehabilitation Institute of Chicago (doing business as Shirley Ryan AbilityLab) to conduct research on improving locomotor function in individuals with chronic incomplete spinal cord injury (SCI). The key objectives of this 2-year grant (Award ID: R03HD114768, August 1, 2024...
This $420,883 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will support research to improve muscle regeneration and restore function following serious traumatic injuries. The University of Missouri System, the prime recipient, will leverage its expertise in microvascular imaging, muscle biology, and biomaterials to investigate the role of fibroadipogenic...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 (Child Health and Human Development Extramural Research) supports research to investigate the use of operant conditioning of motor evoked potentials (MEPs) to target corticospinal plasticity and improve upper limb motor recovery in individuals with cervical spinal cord injury (SCI). The $115,881 award, effective April 15, 2025 through March 31, 2027, will...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), provides $591,304 to the University of Louisville to investigate the role of the integrated stress response (ISR) pathway, specifically the ISR kinase HRI, in the secondary injury and neuroinflammation following traumatic spinal cord injury (SCI). The research aims to define the cell-specific...
This $111,307 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research at the University of Pittsburgh to investigate cerebral spinal fluid (CSF) serotonin and adenosine as biomarkers for detecting secondary injuries in traumatic spinal cord injury (SCI) patients. The research aims to test the hypotheses that: 1) ischemic cord injuries increase CSF serotonin levels, 2) CSF adenosine...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $462,296 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the University of Louisville to conduct research on propriospinal plasticity and recovery after incomplete spinal cord injury. The project aims to investigate the anatomical plasticity exhibited by long-ascending propriospinal neurons (LAPNs) following spinal cord injury, the impact of silencing...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under CFDA 93.865 Child Health and Human Development Extramural Research program, provides $155,348.00 to The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania, to investigate the role of astrocytes in spinal cord injury and regeneration. The research project aims to define the dynamic behavior of astrocytes...
This Project Grant award of $305,447, issued on September 2, 2024 by the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research), aims to identify predictive biomarkers for acute intermittent hypoxia-induced motor recovery in individuals with incomplete spinal cord injury.
The research team from the University of Colorado will: 1) Validate the cellular mechanisms underlying hypoxia-induced plasticity in humans, using enzyme-linked immunoassays to quantify changes in neurotransmitters and growth factors; and 2) Utilize magnetic resonance imaging and transcranial magnetic stimulation to identify predictive biomarkers of responsiveness to the hypoxia intervention. This multi-disciplinary collaboration across the CU campuses in Boulder and Anschutz Medical Campus seeks to optimize the clinical translation of acute intermittent hypoxia therapy for improving walking performance in individuals with chronic, incomplete spinal cord injury.