This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $127,266 to The Regents of the University of Colorado to investigate the relationship between embryonic glucose homeostasis and neural tube closure. The key objectives are to: 1) Examine the role of the insulin receptor substrate 1 (IRS-1) protein in regulating cellular glucose consumption dynamics...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) aims to quantify the impact of hyperglycemia on embryonic metabolism and development in C. elegans. The $474,878 award to the Children's Hospital Medical Center in Cincinnati, Ohio will support a 2-year research project to generate single-cell resolution data on how embryonic metabolism changes over developmental...
This Project Grant award of $364,324 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) supports research to understand the role of retrotransposable elements (RTEs) in neurodevelopment and neurodevelopmental disorders. The key objectives are to: 1) Test the impact of RTE expression and mobilization on brain development in Drosophila and cerebral organoids, using nucleoside reverse...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is providing $2,468,757 to the University of Texas at Austin to conduct research on using magnetic resonance imaging (MRI) to assess maternal and fetal pancreas size and growth over the course of pregnancy. The research aims to establish a model for how maternal pancreas growth interacts with the...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $1,576,519 to the University of Kansas Medical Center Research Institute, Inc. (KUMCRI) to investigate the role of the RNA methyltransferase METTL3 in mammalian placental development and maintenance. The research aims to elucidate how METTL3-mediated RNA modifications regulate...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the federal Child Health and Human Development Extramural Research program (CFDA 93.865), provides $121,920 to the University of North Carolina at Chapel Hill to investigate the role of the protein RFT1 in growth and developmental signaling. The research aims to elucidate how RFT1 regulates hedgehog signaling and downstream mTOR complex 2 pathways, which are key...
This Project Grant award of $601,499 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research to investigate the impact of maternal obesity on mitochondrial function and offspring obesity development. The key objectives of this 5-year grant are to: 1) Determine if transfer of damaged mitochondrial cargo from circulating adipocyte extracellular vesicles (EVs) of obese...
This federal Project Grant award for $152,816.00, provided by the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research), aims to investigate the link between Down's syndrome (trisomy 21) and placentation defects. The research will focus on: Identifying transcriptional differences in implantation-stage trophoblasts between trisomy 21 and euploid induced pluripotent stem cell lines through RNA-sequencing. Assessing the...
This federal Project Grant award of $1,808,868 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to understand the pathophysiological mechanisms driving ciliopathy-associated structural birth defects. The University of Alabama at Birmingham (UAB) will identify and characterize genetic variants of interest from patient and variant repositories,...
This federal Project Grant award of $418,178 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to provide mechanistic insights into the neurobiological mechanisms by which maternal sensitivity is compromised by postpartum depression. Specifically, the University of Massachusetts (UMass), through its Office of Grant & Contract Administration, will use intersectional viral...