Project Grant R01HD115298

Award Date 8/15/24
Completion Date 7/30/29
Dollars Obligated $956K
Federal Grant Program
93.865
Assistance Type
Project Grant
Place of Performance
Hamden, CT 06511, USA
Similar Awards
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under CFDA Program 93.865 "Child Health and Human Development Extramural Research", provides $561,640 to Duke University to conduct research on the signaling and cellular mechanisms that drive notochord patterning in zebrafish. The goal is to elucidate the clock mechanism that times the addition of new mineralized segments along the anterior-posterior axis, as well...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is providing $435,875.00 to the University of Texas at Austin to develop robust and accessible methods for non-invasive quantification of the mechanical properties of cell-cell junctions and the cytoplasm in vertebrate embryos. The goal is to improve the depth and breadth of understanding of embryo biomechanics...
The federal Project Grant award R21HD116006 for $270,000.00, awarded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), will fund research to elucidate the cellular and molecular mechanisms enabling spinal cord regeneration in zebrafish. The primary objectives are to: 1) Analyze cell state changes over time associated with successful versus failed spinal cord...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the federal Child Health and Human Development Extramural Research program (CFDA 93.865), will fund research at the University of Oregon to investigate the role of the neurotransmitter serotonin (5-HT) in controlling spine morphology and spinal deformities. The $409,750 award will enable the researchers to conduct spatial and temporal genetic perturbations to determine...
Yale University was awarded a $3,015,000 Project Grant from the Department of Health and Human Services National Institutes of Health Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) for the period of September 15, 2022 through August 31, 2025. The grant will support research to develop a controllable and scalable in vitro model for studying human embryonic patterning and germ layer differentiation using human pluripotent stem cells and bioengineering...
This federal Project Grant award of $1,508,357.00 was provided by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310). The award will fund research at Yale University to develop "mechaswitches" - universal, modular and programmable signal transduction systems that can trigger specific cellular actions in response to mechanical signals. The goal is to combine state-of-the-art technologies in protein design, RNA...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $393,093 to The Trustees of Columbia University in the City of New York to uncover the interplay between gene expression, cell morphometrics, and tissue-level mechanics during embryonic development. The research aims to develop an integrative, statistical machine learning framework for 4D mammalian development, leveraging...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will provide $495,204 to The Trustees of the University of Pennsylvania to investigate the molecular basis for bone morphogenetic protein (BMP) receptor specialization and trafficking. The research aims to elucidate how specialized receptor functions and trafficking mechanisms fine-tune BMP signal transduction,...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the federal Child Health and Human Development Extramural Research program (CFDA 93.865), provides $142,997 to the University Corporation at Monterey Bay to conduct research on the interaction between migrating cells and their substrate during tissue development. The key objectives are to investigate the role of BMP signaling in substrate morphogenesis driven by...
This federal Project Grant award, with ID K99HD119028, was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The $114,458 award, with a performance period from August 1, 2025 to July 31, 2027, will support research at Duke University to quantitatively investigate how zebrafish appendage regeneration encodes and processes size memory at the cellular...

This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $955,521 to Yale University to conduct a cross-scale analysis of cell-extracellular matrix (ECM) adhesion in early spinal column development using zebrafish as a model organism.

The project aims to quantify the molecular dynamics of single integrin heterodimers, which are the primary cell surface receptors for the ECM, within the neural tube and paraxial mesoderm of the developing spinal column. This research leverages a new single molecule spectroscopy and machine learning protocol developed by the lab to measure the movement and conformational dynamics of proteins in a living embryo for the first time. The findings have the potential to provide insights into the mechanical coupling between the neural tube and paraxial mesoderm that can impact the development of spina bifida and congenital scoliosis. The award period runs from August 15, 2024 to July 30, 2029.

Generated 8/5/25, 6:30 AM