This Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) aims to develop less invasive, novel intervention strategies for endogenous in utero repair of spina bifida. The $1,708,120 award to Baylor College of Medicine will fund research to: 1) Determine the therapeutic efficacy of amniotic fluid-based cell free strategies to modulate the in utero environment and reduce the severity of spina...
This $270,000 federal Project Grant award was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award supports research to elucidate cell state changes and molecular mechanisms associated with spinal cord regeneration versus failure in zebrafish following injury. The project aims to 1) define cell state changes over time related to regeneration and failure, and 2) manipulate...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $487,559 in funding to Yale University to conduct research on the molecular biophysics and systems morphogenesis in early spinal column development using zebrafish as a model. The key focus of the research is to quantify the molecular dynamics of single integrin heterodimers, which are the primary cell...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 Child Health and Human Development Extramural Research program provides $602,956 in funding for research on mechanisms of ciliopathy-associated structural birth defects. The University of Alabama at Birmingham (UAB) is the primary awardee and will leverage their expertise in medicine, genetics, bioinformatics, and animal modeling to: Identify and characterize genetic...
This Project Grant award of $152,816 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to investigate the link between Down's syndrome (trisomy 21) and placentation defects. The key objectives are to: 1) Identify transcriptional differences between trisomy 21 and euploid (normal) induced pluripotent stem cell-derived syncytiotrophoblasts, 2) Assess the role of the...
This federal Project Grant award for $504,888, provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" program (CFDA 93.286), supports the development of an engineered biomaterial to improve the survival and integration of human induced pluripotent stem cell-derived neurons (hiPSC-neurons) transplanted for the treatment of spinal cord injury. Specifically, the...
This Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) supports research on maternal diabetes-induced neural tube defects (NTDs), the second most common birth defects. The $668,211 award to the University of Maryland, Baltimore aims to investigate how maternal diabetes dysregulates RNA metabolism, specifically by repressing miR-322, upregulating the RNA binding protein RBM47, and...
This $305,447 Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) supports research to identify predictive biomarkers for acute intermittent hypoxia (AIH)-induced motor recovery in individuals with incomplete spinal cord injury (ISCI). The research aims to: 1) validate the cellular mechanisms of AIH-induced plasticity in humans as observed in rodent studies, and 2) use magnetic resonance...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $156,500.00 to the University of Hawaii at Manoa to develop an in vitro "yolk sac organoid" model using human pluripotent stem cells. The objectives are to: 1) characterize the cellular and molecular properties of the stem cell-derived cysts to understand which yolk sac cell types are...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is providing $435,875.00 to the University of Texas at Austin to develop robust and accessible methods for non-invasive quantification of the mechanical properties of cell-cell junctions and the cytoplasm in vertebrate embryos. The goal is to improve the depth and breadth of understanding of embryo biomechanics...