This federal Project Grant award, funded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to investigate the impact of obesity and adiposity on the human endometrium. The $195,000 award, with a performance period from August 1, 2024 to July 31, 2026, will support three key research activities: Single-nucleus RNA sequencing to comprehensively understand how pathologic adiposity may influence alterations in endometrial cellular populations. Liquid chromatography mass spectrometry to assess for altered proteomic profiles in the endometrium. Functional endometrial assays to correlate the observed transcriptomic and proteomic signatures with markers of endometrial dysfunction. By disentangling the effects of obesity from co-occurring conditions, this project seeks to provide novel insights into the well-established link between obesity, infertility, and early pregnancy loss. These pilot experiments will guide planning for future large-scale validation and mechanistic studies.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | ($14k) | 7/31/24 | ||
| Not listed | $209.0k | 7/30/24 |