Project Grant R21HD113812

Award Date 8/1/24
Completion Date 7/31/26
Dollars Obligated $195K
Federal Grant Program
93.865
Assistance Type
Project Grant
Place of Performance
Michigan, USA
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  1. Single-nucleus RNA sequencing to comprehensively understand how pathologic adiposity may influence alterations in endometrial cellular populations.

  2. Liquid chromatography mass spectrometry to assess for altered proteomic profiles in the endometrium.

  3. Functional endometrial assays to correlate the observed transcriptomic and proteomic signatures with markers of endometrial dysfunction.

By disentangling the effects of obesity from co-occurring conditions, this project seeks to provide novel insights into the well-established link between obesity, infertility, and early pregnancy loss. These pilot experiments will guide planning for future large-scale validation and mechanistic studies.

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