This Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research program) provides $2,163,115 in funding to The University of Texas Health Science Center at San Antonio to conduct research aimed at disentangling the genetic mechanisms of endometriosis severity using single-cell multi-omics approaches. The research project, scheduled to run from September 1, 2024 to May 31, 2029, will involve...
This $643,049 Project Grant, awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports the development of a physiomimetic tissue engineering model to investigate the initiation and progression of endometriosis lesions. The research program aims to uncover how the ovarian microenvironment and vascular signals influence the adhesion and invasion of endometriotic epithelial and...
This $675,852 Project Grant award was provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) to investigate the pathophysiology of adenomyosis, a common uterine disorder, at the single-cell level. The primary goal is to use advanced single-cell analytics and drug discovery approaches to identify novel or repurposed drugs that can reverse the adenomyosis phenotype and alleviate associated symptoms. The work involves creating a detailed...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $233,250 to support research into the peripheral and central mechanisms underlying endometriosis pain. The study aims to identify factors related to endometriosis pain, including the role of local and systemic estrogen levels, estrogen receptor expression, and conditioned pain modulation response....
This federal Project Grant award of $509,220 from the National Institute of Neurological Disorders and Stroke (part of the National Institutes of Health) under the Drug Use and Addiction Research Programs (CFDA 93.279) aims to advance the understanding and treatment of endometriosis-associated pain. The research will validate drugs that block neuroimmune communication and macrophage-targeting drugs as novel, non-hormonal, and non-opioid approaches for endometriosis pain management. Key...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $250,206 to the University of Arizona to study the structural and functional differences in the uterotubal junction (UTJ) of women with and without endometriosis. The key objectives are to: 1) Compare functional and morphological measures of explanted UTJs from women with and without endometriosis...
This $2,045,782 Project Grant awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) aims to develop the first disease-modifying, non-hormonal therapeutic for endometriosis. The funding will support the manufacturing of the investigational drug ENDO-205 to the quality standards required for human clinical trials, as well as the completion of nonclinical safety and pharmacology...
This federal Project Grant award of $461,320 from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) will support a study to investigate risk factors and consequences of endometriosis among Black women. The primary awardee, the Fred Hutchinson Cancer Center, will leverage data from the Black Women's Health Study, a long-running cohort of 59,000 Black women, to examine associations between established endometriosis...
This federal Project Grant award for $131,085 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will support research to gain a better understanding of the role of uterine natural killer (UNK) cells in the pathobiology of endometriosis. The primary objectives are to characterize the receptor repertoire and functional capacity of UNK cells in women with and without endometriosis,...
This $20,000 federal Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) aims to develop a novel, noninvasive method for early detection of endometriosis using biological neural circuit-based gas sensors. The project, led by the collaborative research partnership of Henry Ford Health and Michigan State University Health Sciences, involves two key objectives: Detecting and distinguishing endometriosis...