This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research to investigate the immunometabolic dysregulations in the offspring of obese mothers. The $234,000 award, effective from April 1, 2025 to March 31, 2027, will be provided to Oregon Health & Science University to conduct this research.
The key objectives of the project are to: 1) conduct a pre-clinical trial using low-dose aspirin in pregnant mice to reduce the risk of obesity and metabolic diseases in their offspring, and 2) determine whether the metabolic dysregulations observed in the bone marrow cells of 3-week-old offspring of obese mothers lead to chronic inflammation and metabolic disease in adulthood. The research aims to elucidate the underlying mechanisms by which maternal obesity can initiate a transgenerational cycle of obesity and metabolic disorders through immunometabolic reprogramming in the offspring.
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