Project Grant R21EY037882
- Federal Grant Award Summary Duke University's Office of Research Administration received a $127,718 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective December 21, 2025, through April 30, 2028. The award funds research into the neural mechanisms of visuomotor transformations in larval zebrafish (Danio rerio), with the primary deliverable being a cellular-level mechanistic characterization of the neural circuits underlying visually...
- Federal Grant Award Summary Duke University received a $675,193 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded September 1, 2025, with completion expected June 30, 2028. The grant supports research into gene therapy targeting complement factor H (CFH) and lipoprotein dynamics in age-related macular degeneration (AMD). The research leverages novel animal models developed by the investigative team that integrate advanced age, complement...
- Federal Grant Award Summary Emory University received a $391,250 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded July 1, 2025, with a completion date of June 30, 2030. The award supports basic science research investigating how visual input influences neuronal signaling pathways related to myopia (nearsightedness) development. The project will employ single-cell electrophysiological recordings to examine ON and OFF retinal pathway...
- Federal Grant Award Summary The University of North Carolina at Chapel Hill received a $603,053 Project Grant from the National Eye Institute (CFDA 93.867, Vision Research program) awarded April 15, 2026, with completion scheduled for March 31, 2030. This grant funds the development and optimization of a gene therapy targeting IMPG2-associated retinal degeneration, which currently affects patients with juvenile-onset rod-cone dystrophy and adult-onset vitelliform macular dystrophy. The primary...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $638,625 Project Grant to the University of California, San Diego, effective August 1, 2025 through July 31, 2028, under the Vision Research program (CFDA 93.867). The award funds research to investigate the mechanisms of drusen formation in age-related macular degeneration (AMD), a leading cause of blindness affecting approximately 196 million people globally. The research employs a novel quartz crystal microbalance assay...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded the University of California, Irvine a Project Grant of $158,960 under the Vision Research program (CFDA 93.867) to develop scalable prime editor evolution for correction of inherited retinal diseases. The award, effective September 30, 2026, with completion targeted for September 29, 2029, funds research to advance precision genome-editing technologies beyond current limitations of CRISPR-Cas9 by generating optimized prime...
- Federal Grant Award Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded $830,024 to the University of Colorado-Denver for a two-year project (September 1, 2025 – August 31, 2027) titled "Elucidating Competence and Fate Choice Dynamics During Retinal Development." This research project will produce fundamental scientific findings and empirical data aimed at understanding how the Notch signaling pathway regulates cell fate specification...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $435,052 Vision Research (CFDA 93.867) Project Grant to the University of Massachusetts Boston for the period July 1, 2025 through June 30, 2029. This research project will investigate the molecular and genetic mechanisms that control photoreceptor subtype specification for color vision in the fruit fly (Drosophila melanogaster) retina as a model system. The research will identify conserved transcription factors and...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a Project Grant of $896,500 under the Vision Research program (CFDA 93.867) to The Research Foundation For The State University of New York, performing at Upstate Medical Center in Syracuse, New York. The award, effective September 1, 2025, through August 31, 2027, funds research into the transcriptional dynamics of photoreceptor gene regulation, specifically investigating how the homeodomain transcription factor CRX...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded University of California, Irvine $179,964 under the Vision Research program (CFDA 93.867) on March 1, 2025, for a project grant extending through July 10, 2029. The project focuses on developing deep learning-based biomarkers for optic neuropathies using retinal Optical Coherence Tomography (OCT) imaging analysis. The research will employ advanced computational techniques, including deep generative models, neural field image...
Duke University's Office of Research Administration received a $405,373 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded June 1, 2026, with a completion date of May 31, 2028. The grant funds fundamental research to characterize bicornuate cones, a novel type of photoreceptor cell recently identified in the human retina that contains two fully developed outer segments emanating from a single cell soma—a significant discovery that challenges conventional understanding of human cone morphology. Research deliverables will include high-resolution ultrastructural analysis using three-dimensional electron tomography to determine the number of centrioles in the inner segments of these cells, which will elucidate the mechanism of twin outer segment formation, and identification of visual pigments expressed by bicornuate cones along with mapping of their abundance and spatial distribution across the retina. This investigation directly supports the NEI's mission to drive innovative research aimed at understanding the eye and visual system. The two-year project will advance fundamental knowledge of human photoreceptor biology that may have implications for understanding retinal function and potentially for research on vision-related diseases and disorders.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $405.4k | 6/5/26 |