Project Grant R01EY037246
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded The University of Iowa a $440,263 Project Grant on May 1, 2026, under the Vision Research program (CFDA 93.867) to investigate osmotic regulation mechanisms in cone dystrophy with supernormal rod response (CDSRR). The research focuses on understanding how mutations in the KV2.1/KV8.2 potassium channel—which causes CDSRR and progressive macular degeneration beginning in early childhood—disrupts potassium homeostasis...
- Federal Project Grant Award Summary New York University School of Medicine received a $546,439 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded April 15, 2026, with an ultimate completion date of March 31, 2030. This award funds research to develop corneal stromal keratocyte modeling from human cornea organoids (HCOs) derived from induced pluripotent stem cells (iPSCs). The research aims to generate novel therapeutic cell sources and...
- Federal Grant Award Summary Wayne State University received a $586,258 Project Grant award from the National Eye Institute (CFDA 93.867 – Vision Research) effective July 1, 2025, through April 30, 2029. The award funds a research investigation titled "The Role of Eosinophils in Modulating the Corneal Response to Infection," which seeks to characterize how eosinophils—a type of innate immune cell—influence corneal inflammation and tissue damage during Pseudomonas aeruginosa-induced...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $421,136 Project Grant to the University of Maryland, College Park, effective August 1, 2025, through July 31, 2027, under the Vision Research program (CFDA 93.867). This award supports research into advanced wavefront shaping techniques designed to enable high-resolution fundus imaging in patients with ocular opacities—conditions affecting the cornea and lens that currently prevent effective posterior segment eye...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $431,750 Project Grant to the University of California, Irvine under the Vision Research program (CFDA 93.867) for the period May 1, 2026 through April 30, 2028. This award funds exploratory research investigating novel mechanisms underlying obstructive meibomian gland dysfunction (O-MGD), a condition characterized by altered meibum lipid synthesis that leads to duct dilation and dry eye disease. The research will produce...
- Federal Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded the University of Missouri System $430,825 on May 1, 2026, to support a two-year research project investigating corneal damage resulting from traumatic brain injury (TBI). The research will generate empirical findings on the neuroinflammatory mechanisms linking TBI-induced cranial dura mater (CDM) injury to corneal dysfunction through the trigeminal ganglion sensory pathway. The...
- Federal Grant Award Summary Wayne State University received a $428,152 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded August 1, 2025, with a completion date of July 31, 2030. This research initiative investigates the role of matriptase, a cell-surface anchored serine protease, in corneal epithelial homeostasis and repair. The project delivers basic and translational science research utilizing novel matriptase knockout mouse models and...
- Federal Grant Award Summary Miami University received a $467,969 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) on April 15, 2026, with a completion date of March 31, 2031. The project, "FOXE3 in Creating Lens Chromatin Architecture and Transcriptional Identity," will deliver fundamental research products focused on understanding the molecular mechanisms by which the FOXE3 transcription factor regulates lens cell identity and...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded The Schepens Eye Research Institute, Inc. a Project Grant totaling $540,213 under the Vision Research program (CFDA 93.867) to investigate the fibrosis-immunity interface in corneal transplantation. Beginning August 1, 2025, and extending through July 31, 2030, this research program will deliver scientific findings aimed at improving corneal transplant survival rates by elucidating the mechanisms by which myofibroblasts...
- Federal Grant Award Summary The University of North Texas Health Science Center at Fort Worth received a $249,000 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded on April 15, 2026, with a completion date of March 31, 2029. The award funds research aimed at identifying non-surgical therapeutic interventions for keratoconus, a progressive corneal disorder affecting approximately 1 in 500 to 2,000 Americans. The primary research...
The University of Iowa received a $641,479 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective May 1, 2026, through February 28, 2031. The award funds research to identify the molecular signals and mechanisms leading to the onset and progression of Fuchs Endothelial Corneal Dystrophy (FECD), a blinding disease affecting 4-7% of individuals over age 40 with an estimated annual economic burden of $300 million. The research leverages a newly developed mouse model that replicates major FECD phenotypes—including guttae (sub-endothelial blebs), corneal endothelial cell loss, and corneal edema—to address a critical knowledge gap that has historically hindered therapeutic development for this condition. The project deliverables include empirical research findings addressing two specific aims: (1) determining the role of Descemet's membrane changes in corneal endothelial function, and (2) determining the role of ubiquitin-proteasome system inactivity in FECD phenotype development. These findings are expected to advance understanding of the disease mechanisms and inform the development of alternative therapies beyond the current standard treatment of corneal transplantation, which carries significant risks including graft rejection and secondary ocular complications. The research will be conducted at the University of Iowa's Bloomington, Indiana facility.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $641.5k | 5/1/26 |