Project Grant R21EY038707
- The National Institute of Neurological Disorders and Stroke (part of the National Institutes of Health) awarded $361,125 to the University of California, Berkeley on September 1, 2026, under the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372) as a project grant. The award funds a targeted planning project to establish a functional connectomics paradigm combining ultra-fast two-photon voltage imaging (2P-FACED) with two-photon optogenetic...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372), provides $828,335 to the University of Chicago to investigate the roles of inhibitory and disinhibitory neural circuits in the formation, stabilization, and competition of neural assemblies in the cortex. The project aims to experimentally test theoretical...
- The Johns Hopkins University was awarded a $2,008,605 Project Grant under the National Institute of Neurological Disorders and Stroke's 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372). The grant funding will support the development of an "Autonomous Rapidly Adaptive Multiphoton Microscope for Neural Recording and Stimulation." This adaptive multiphoton microscope system will leverage hybrid volumetric scanning,...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Utah $616,000 on August 1, 2026, under the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (Assistance Listing 93.372) to develop a high-throughput computational pipeline for rapid design of photocaged neuropeptides. The project addresses the NIH BRAIN Initiative goal to enable precise modulation of neural circuit components by creating a generalizable, open-source...
- The National Institute of Neurological Disorders and Stroke awarded a Cooperative Agreement totaling $387,647 to The Regents of the University of California, San Francisco on May 1, 2026, under the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372). UCSF will develop a personalized multisite closed-loop deep brain stimulation (DBS) device platform targeting chronic pain. The work includes designing a brain stimulation system that delivers electrical...
- The National Institute of Neurological Disorders and Stroke awarded the University of Alabama at Birmingham a $644,394 cooperative agreement on May 1, 2026, under the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372) to conduct a controlled first-in-human assessment of spinal cord stimulation as a treatment for primary, treatment-resistant restless legs syndrome. The research will evaluate the safety, patient acceptance, and preliminary...
- The National Institute of Neurological Disorders and Stroke awarded $462,148 to The Trustees of Columbia University in the City of New York on July 8, 2026, under the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372). Columbia will develop and benchmark functional graphene nanoribbon (F-GNR) neural probes as ion-selective, multimodal recording tools for neuroscience. The project addresses the lack of existing tools with sufficient molecular...
- This $423,151 CAREER grant awarded by the National Science Foundation (NSF) Engineering program (CFDA 47.041) supports the development of a new ultrasound imaging technology to enable high-resolution functional mapping of the human brain. The project aims to overcome limitations of current brain imaging methods by leveraging deep learning and ultrafast ultrasound imaging to achieve microscopic spatial resolution and deeper tissue penetration. If successful, this transformative new imaging...
- The National Institute of Neurological Disorders and Stroke awarded Cornell University a $686,023 Cooperative Agreement on July 8, 2026, to develop non-invasive optical imaging technology for visualizing brain structure and function at the cellular level. Cornell will advance three-photon microscopy (3PM) imaging techniques and develop new lasers to increase three-photon fluorescence signal by approximately 10,000 times. This advancement will enable visualization of mouse brain activity with...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Pittsburgh $587,678 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to elucidate immune cell trafficking and biodegradation of bioscaffolds implanted in brain tissue using multi-color 19F magnetic resonance imaging. The research visualizes the spatio-temporal dynamics of peripheral immune cell accumulation and invasion into...
The National Institute of Neurological Disorders and Stroke awarded the University of Illinois $599,169 on September 1, 2026, under the 21st Century Cures Act — Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, CFDA 93.372, to develop and validate contrast-free super-resolution ultrasound imaging techniques for functional imaging of neural circuits in the spinal cord. The research demonstrates phase subtraction imaging (PSI) and null subtraction imaging (NSI) as novel tools for functional ultrasound imaging of spinal cord blood flow without contrast agents, achieving spatial resolution better than ten micrometers. The work targets improved understanding and treatment of chronic pain by developing spatiotemporal biomarkers that correlate pain to specific nerve bundles in the spine, with application to optimizing spinal cord stimulation therapy for neuropathic pain conditions refractory to pharmacologic treatment. Performance occurs in Urbana, Illinois through August 31, 2029. The BRAIN Initiative aims to accelerate development and application of innovative neurotechnologies enabling researchers to produce a dynamic picture of brain and neural circuit function across time and space, with the goal of advancing prevention and treatment of brain disorders.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $599.2k | 8/21/26 |