Project Grant R01NS142114
- Federal Grant Award Summary The University of Pittsburgh received a $624,368 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded May 15, 2026, with a completion date of April 30, 2031. This research initiative investigates the neural basis of brain resting state activity—the spontaneous, structured patterns of brain activity observed during...
- Federal Project Grant Award Summary The University of Pittsburgh received a $2.35 million Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded September 8, 2025, with completion targeted for June 30, 2029. The research project investigates the pathological mechanisms of blood-cerebrospinal fluid (CSF) barrier dysfunction in vascular cognitive...
- Federal Project Grant Award Summary The University of Pittsburgh received a $550,000 Project Grant from the National Science Foundation's Division of Chemical, Bioengineering, Environmental, and Transport Systems (Engineering program, CFDA 47.041) awarded June 15, 2026, with a completion date of May 31, 2029. The project delivers research and development focused on improving brain-computer interface (BCI) longevity through lysosome-directed gene therapy strategies. The primary deliverable is...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Pittsburgh $416,544 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program on June 1, 2025, with completion anticipated by May 30, 2027. This Project Grant supports the development and validation of novel non-invasive imaging tools for evaluating therapeutic efficacy in Leigh Syndrome, a severe childhood-onset...
- Federal Grant Award Summary The University of Pittsburgh received a $650,057 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective September 1, 2026 through August 31, 2031. This award supports fundamental research to elucidate the molecular mechanisms by which MATR3 (matrin-3) mutations drive neurodegeneration in amyotrophic lateral sclerosis...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $224,265 to the University of Pittsburgh under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective August 1, 2025, through July 31, 2030. This Career Development Award supports the development and refinement of novel interventions to improve neurological prognostication for patients with hypoxic-ischemic brain injury...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Pittsburgh a Project Grant of $109,062.00 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant, effective August 7, 2025, through July 31, 2030, funds a predoctoral training program in basic neuroscience at the Center for Neuroscience at the University of Pittsburgh (CNUP). This award replaces an expired T32...
- Federal Grant Award Summary The University of Pittsburgh received a $437,250 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded May 5, 2026, with completion targeted for January 31, 2031. This research initiative will develop a generalizable computational platform that integrates systemic omics data (proteomics, metabolomics, transcriptomics), imaging-derived phenotypes, and genetic...
- Federal Grant Award Summary The University of Pittsburgh received a $620,504 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded February 11, 2026, with completion targeted for November 30, 2030. This research grant funds basic neuroscience investigation into how the brain prioritizes competing survival needs and resolves chronic pain signaling....
- Federal Grant Award Summary The University of Pittsburgh received a $157,788 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective April 6, 2026, with a completion date of March 31, 2031. This award supports investigator-initiated biomedical research investigating interleukin-33 (IL-33) signaling as a therapeutic mechanism to address progressive multiple sclerosis (MS). The research...
The University of Pittsburgh received a $587,678 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective June 1, 2026 through May 31, 2031. This award funds research to elucidate the role of immune response in bioscaffold implantation using multi-color 19F (fluorine-19) magnetic resonance imaging (MRI). The research will deliver non-invasive imaging techniques to visualize the spatio-temporal dynamics of immune cell accumulation and invasion into extracellular matrix hydrogels implanted in brain tissue cavities formed by stroke, utilizing perfluorotertbutyl-cyclohexane and perfluorocrownether labeling agents to distinctly visualize the bioscaffold and peripheral immune cell invasion simultaneously over time. The grant supports fundamental research objectives to timestamp different phases of peripheral immune cell invasion by 19F MRI, monitor in vivo immune cell ablation, and investigate immune cell contributions to hydrogel biodegradation and tissue regeneration. The anticipated outcomes include improved mechanistic understanding of immune cell trafficking between host and bioscaffold, with potential applications for developing novel methods to optimize the immune response for enhanced bioscaffold integration and tissue regeneration in neurological injury contexts.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $587.7k | 5/25/26 |