Project Grant R21EY038004
- This Project Grant award for $679,159 from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports research on in vivo epigenetic reprogramming of retinal ganglion cells (RGCs) in aging mice with glaucoma. The research aims to identify new therapeutic targets for glaucoma that can protect and rejuvenate RGCs, which are specifically targeted and damaged in this disease leading to vision loss. The 4-year project, awarded to The Schepens Eye...
- The National Eye Institute (NEI), under the Department of Health and Human Services, has awarded a $695,050 Project Grant to The Leland Stanford Junior University (Stanford University) to investigate the role of cholinergic dysfunction in the pathogenesis of glaucoma. The grant, funded through the NEI's Vision Research program (CFDA 93.867), aims to leverage advanced magnetic resonance imaging (MRI) and spectroscopy (MRS) techniques to identify and quantify cholinergic changes in the visual...
- This $460,625 Project Grant was awarded by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) to Yale University. The grant will fund research to investigate the cellular and synaptic mechanisms underlying changes in retinal ganglion cell (RGC) activity following optic nerve injuries in mouse models of glaucoma. Specifically, the project aims to (1) determine the underlying mechanisms for altered RGC activity after increased intraocular pressure or...
- This Project Grant award of $423,767 from the National Eye Institute (CFDA 93.867 - Vision Research) supports research at the University of California, Davis focused on understanding the role of myeloid cells in glaucoma-related axonal degeneration. The project aims to determine whether NAD+-based interventions can protect retinal ganglion cell axons in a glaucoma-relevant model of axon injury, and to characterize the associated immune response. The research will leverage novel axon injury...
- This Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) provides $127,861 to The Regents of the University of California, Berkeley to conduct research on the role and regulation of a distinct optic nerve microglia population in glaucomatous neuropathy. The research aims to elucidate how the lipoxin LXB4 regulates disease-associated microglia (DAM) in the optic nerve during ocular hypertension, a key mechanism in the neuroprotective effects of LXB4 against...
- This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), provides $502,677 to The Leland Stanford Junior University (Stanford University) to develop chemical modulators of endoplasmic reticulum (ER) stress as neuroprotective treatments for glaucoma. The research aims to optimize promising ER stress modulator compounds identified through high-throughput screening, evaluate their efficacy in mouse models of glaucoma, and...
- This $417,162 Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) supports research on using optical techniques to detect early signs of glaucoma, the leading cause of irreversible blindness worldwide. The University of Houston System, the grantee, will conduct research to determine if changes in the birefringence (optical properties) of the lamina cribrosa and posterior eye structures can serve as sensitive early indicators of glaucoma before structural damage...
- This $439,016 federal Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) aims to provide initial proof-of-concept for a novel therapeutic approach to glaucoma. The goal is to target the progressive TGFβ2-associated aqueous outflow pathway pathology in a feline model of early onset glaucoma. The project involves optimizing viral vector-mediated transduction of feline trabecular meshwork cells to suppress pathologic TGFβ2 signaling, which contributes to increased...
- This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides funding to researchers at the University of California, San Francisco (UCSF) to study the neural mechanisms underlying visual processing and behavior after photoreceptor degeneration. The $237,588 award, spanning June 2025 through December 2027, will leverage the vertical optokinetic reflex (OKR) - a visual behavior that tracks global motion - to investigate how cone degeneration disrupts noise...
- This federal Project Grant award of $764,881 from the National Eye Institute (CFDA 93.867 - Vision Research) supports research to investigate the role of advanced glycation end products (AGEs) in primary open-angle glaucoma (POAG). The overarching hypothesis is that the accumulation of AGEs in the trabecular meshwork promotes extracellular matrix remodeling and cell dysfunction, leading to increased outflow resistance and elevated intraocular pressure in POAG. The research project has two...
The National Eye Institute (NEI) awarded a $451,000 Project Grant under the Vision Research federal grant program (CFDA 93.867) to The Regents of the University of California, San Francisco (UCSF) to conduct a multimodal characterization of a novel inherited mouse model of glaucoma. The research aims to evaluate structural and functional changes in the mouse model, including axonal degeneration, retinal ganglion cell loss, dendritic changes, and neuroinflammatory responses. It will also identify molecular pathways associated with glaucomatous neurodegeneration using single cell RNA sequencing of retinal ganglion cells. This project grant will run from September 1, 2025 to August 31, 2027 and supports UCSF's work to develop a better understanding of the underlying mechanisms of primary open-angle glaucoma, a leading cause of blindness worldwide.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $451.0k | 8/13/25 |