This Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) supports the development and validation of a nanoparticle-based therapy called TRE-D-DASA to treat corneal neovascularization (CONV), a sight-threatening condition characterized by abnormal blood vessel growth in the cornea. The $482,067 award will fund research to: 1) synthesize and characterize the TRE-D-DASA conjugate and a fluorescent version for imaging; 2) assess the biodistribution, pharmacokinetics,...
This Project Grant award from the National Eye Institute (NEI), under the federal Vision Research program (CFDA 93.867), supports research to investigate the relationship between myofibroblasts and alloreactive T cells in corneal transplantation. The $540,213 award to The Schepens Eye Research Institute, Inc., effective August 1, 2025 through July 31, 2030, aims to: 1) define the mechanisms by which myofibroblasts regulate alloreactive effector T cell function, and 2) define the mechanisms by...
This federal Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $428,152 to Wayne State University to support research on the role of the protease matriptase in maintaining corneal epithelial barrier function and promoting corneal tissue repair. The award will fund a 5-year project to utilize mouse models and 3D cellular models of the human cornea to characterize matriptase's function in corneal homeostasis and identify its substrates and signaling...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports research to understand the development and function of corneal lens-secreting cells in the human eye. The $543,037 award, effective September 1, 2024 through May 31, 2028, will fund investigations into the genetic and molecular mechanisms underlying corneal development and function. Key research objectives include identifying transcription factors and...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides $237,996 to investigate groundbreaking approaches for in-vivo high-resolution imaging of fine corneal structures. The award aims to develop a speckle illumination holographic imaging system with polarization and phase-sensitive detection, enabling wide field-of-view and 3D imaging capabilities to overcome limitations of current corneal imaging techniques. If successful,...
The National Eye Institute (NEI) awarded a $451,962 Project Grant (CFDA 93.867 Vision Research) to The Regents of the University of California, San Francisco (UCSF) to develop novel mouse models for studying the role of Transcription Factor 4 (TCF4) trinucleotide repeat expansions in the pathogenesis of Fuchs Endothelial Corneal Dystrophy (FECD). The research aims to generate and characterize TCF4 repeat expansion mouse models, as well as to investigate how the TCF4 repeat expansion...
This federal Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) provides $246,000 to The Regents of the University of California, San Francisco to conduct research on serum components that support corneal health. The goal is to define the combinations of serum factors, such as growth factors, signaling lipids, and vitamins, that can restore healthy corneal function and treat diverse ocular surface disorders. The research aims to improve the clinical use of...
The National Eye Institute (NEI) awarded a $225,772 Project Grant (CFDA 93.867 - Vision Research) to The Research Foundation For The State University Of New York, doing business as Stony Brook University, to develop a terahertz time-domain spectroscopy (THz-TDS) imaging system that can accurately measure and map corneal hydration gradients. The project aims to: Determine the accuracy of the THz-TDS corneal scanner in measuring hydration levels in corneal phantoms and ex vivo models. Evaluate the...
The National Eye Institute (NEI) awarded a Project Grant (CFDA 93.867 - Vision Research) in the amount of $753,189 to Trustees of Boston University, doing business as Boston University Medical Campus, with a period of performance from August 1, 2024 to May 31, 2029. The grant will support research to identify novel therapeutic targets for corneal epithelial defects by revealing the differential roles of basal epithelial cells in the central cornea, limbus, and conjunctiva in corneal health and...
This $433,125 federal Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) to The Ohio State University will support research to characterize the function of delta-catenin and the structure of the tricellular adherens junctional complex in lens fiber cells. Specifically, the research aims to test the requirement of delta-catenin for lens function and identify the protein interactions within the tricellular adherens junction. This work will provide the first...