The federal Project Grant award of $433,125.00, awarded by the National Eye Institute (CFDA 93.867 Vision Research program), supports research aimed at inhibiting corneal neovascularization (CNV) by targeting tissue factor (TF). The Ohio State University will conduct studies to define dosages and time windows for systemically administering a TF-targeting agent (L-ICON3) as a monotherapy, as well as determine potential synergistic effects of L-ICON3 combined with other tissue repair factors, to...
This $332,179 Project Grant awarded by the National Eye Institute (CFDA 93.867 Vision Research) supports the development of nanobarrier contact lenses that can provide sustained delivery of the drug cysteamine to treat the ocular complications of cystinosis. The lenses are designed to replace the current 8-times daily eye drop regimen, improving patient compliance and reducing side effects from the preservatives and acidic pH in the eye drops. The project aims to demonstrate the lenses can...
This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $615,979 to Wayne State University to investigate a promising peptide-based combination therapy that targets hyperglycemia-responsive circuits in the cornea to prevent high glucose-induced damage and restore structure and function in the diabetic cornea. The award supports in vitro and in vivo assessments to establish the therapeutic role of the TB4 and VIP combination treatment and elucidate the...
This Project Grant award from the National Eye Institute (NEI), under the federal Vision Research program (CFDA 93.867), aims to advance the development of the drug filociclovir (FCV) for the treatment of adenoviral conjunctivitis and epidemic keratoconjunctivitis. The $674,963 award to Microbiotix, Inc. will fund the completion of key preclinical activities, including finalizing the eye drop formulation, conducting IND-enabling toxicology studies in rabbits and rats, and completing regulatory...
The National Eye Institute (NEI) awarded a $586,258 Project Grant under the Vision Research program (CFDA 93.867) to Wayne State University to conduct research on the role of eosinophils in modulating the corneal response to Pseudomonas aeruginosa infection. The research, spanning from Jul 1, 2025 to Apr 30, 2029, aims to characterize the spatiotemporal distribution, phenotypic profiles, and proteomic changes of eosinophils during corneal inflammation and infection using mouse models. The...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides $237,996 to investigate groundbreaking approaches for in-vivo high-resolution imaging of fine corneal structures. The award aims to develop a speckle illumination holographic imaging system with polarization and phase-sensitive detection, enabling wide field-of-view and 3D imaging capabilities to overcome limitations of current corneal imaging techniques. If successful,...
This $185,000 Project Grant award from the National Eye Institute (NEI) under CFDA 93.867 (Vision Research) supports research to discover novel disease-modifying therapies for the prevention and treatment of glaucoma. The primary awardee, the University of North Texas Health Science Center at Fort Worth, will employ computational pharmacology approaches to identify small molecule inhibitors that can interfere with the GREM1-BMP protein-protein interaction, a key pathogenic mechanism contributing...
This $421,600 Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) will support research at Tufts Medical Center in Boston, MA to investigate the regulatory mechanisms governing retinal neovascularization. The research aims to delineate the role of chemokine signaling in recruiting peripheral immune cells to facilitate pathological vascular growth, as well as the role of microglial complement receptors in regulating neovessel regression. The project will utilize...
This $201,825 Project Grant award from the National Eye Institute (NEI) Vision Research program (CFDA 93.867) supports research to evaluate the use of condensin inhibitors as a potential topical treatment for Pseudomonas aeruginosa bacterial eye infections. The lead investigator, Dr. Valentin Rybenkov at the University of Oklahoma, will collaborate with Dr. Michelle Callegan at the University of Oklahoma Health Sciences Center to conduct in vivo studies examining the toxicity, corneal...
The National Eye Institute (NEI) awarded a $488,639 Project Grant under the Vision Research federal grant program (CFDA 93.867) to the University of Pittsburgh to identify the mechanisms underlying the enhanced virulence of an extensively drug-resistant (XDR) strain of Pseudomonas aeruginosa that has caused a concerning outbreak of keratitis infections. The funding will support research to systematically test the unique virulence factors of this outbreak strain and develop more effective...
This Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) supports the development and validation of a nanoparticle-based therapy called TRE-D-DASA to treat corneal neovascularization (CONV), a sight-threatening condition characterized by abnormal blood vessel growth in the cornea. The $482,067 award will fund research to: 1) synthesize and characterize the TRE-D-DASA conjugate and a fluorescent version for imaging; 2) assess the biodistribution, pharmacokinetics, and toxicity of TRE-D-DASA in a rat CONV model; and 3) determine the dose-response efficacy of TRE-D-DASA in two clinically relevant CONV models. The awardee, Washington State University, will leverage its expertise in nanotherapeutics and corneal disease research to advance this novel targeted therapy, which aims to overcome limitations of current CONV treatments.