This $400,000 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to understand the earliest events in podocyte injury in collagen IV nephropathies. The goal is to investigate how processing of mutant collagen IV proteins injures podocytes at early stages, leading to chronic kidney disease and renal failure. The research uses...
This $166,643 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports the development of robust phenotyping pipelines for early detection of collagen type IV-associated nephropathy (COL4A-AN) using electronic health records (EHR) data. The primary goal is to establish scalable phenotyping methods that leverage natural language processing (NLP) and...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $436,277 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of Delaware. The grant titled "NEPHROGENESIS ON A CHIP: AN SIMPLE MODULAR PLATFORM TO SPATIALLY PATTERN EXTRACELLULAR MATRIX, STROMAL CELLS, AND SOLUBLE FACTORS" aims to develop an easy-to-use 3D in vitro model of the developing nephron that allows spatial patterning...
The U.S. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $243,750 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Trustees of the University of Pennsylvania. The grant will fund the development of novel methods to improve detection of mosaic chromosomal alterations (MCA) in non-neoplastic tissues like the kidney and blood. The project aims to create single-cell sequencing techniques and spatial...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is focused on developing novel bioengineered regenerative medicine solutions based on vasculogenic regenerative medicine technology. The $543,826 award, granted on December 10, 2024, aims to investigate the mechanisms underlying in vivo vasculogenic reprogramming, specifically examining...
This $820,119 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research focused on elucidating the mechanobiological functions of novel cytoskeletal structures in podocytes to reveal new therapeutic opportunities for kidney glomerular diseases. The primary research aims to better understand the mechanisms underlying podocyte homeostasis,...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $163,825 to The Regents of the University of Colorado, doing business as the University of Colorado-Denver, to study the role of AXL signaling in intestinal fibrosis associated with Crohn's disease. The research aims to unravel the intricacies of the GAS6/AXL signaling pathway and how...
This federal Project Grant award of $454,155.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research at the University of Rochester to investigate the role of the S100A4 protein in the development and resolution of post-operative abdominal adhesions. The research aims to comprehensively define the molecular mechanisms underlying adhesion formation, determine...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $208,428 to The Regents of the University of California, San Francisco (UCSF) to enhance the safety and efficacy of stem cell-derived islet transplantation for treating type 1 diabetes. The key focus is on utilizing CRISPR-mediated genome engineering to improve islet cell engraftment,...
This $675,480 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to develop a novel therapeutic compound for treating chronic kidney disease (CKD). The awardee, Fibrotherapeutics Inc., is conducting preclinical studies to evaluate the efficacy, safety, and therapeutic index of a modified, water-soluble, orally-active peptide derived...