Project Grant R01DK141513
Award Date
12/10/24
Completion Date
11/30/28
Dollars Obligated
$544K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
Pittsburgh, PA 15219, USA
Similar Awards
This Project Grant award, funded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), supports the preclinical optimization and design for manufacturability of immunoregulatory tissue-engineered vascular grafts (TEVGs).
The University of Pittsburgh, the prime awardee, will perform final in vitro analysis and in vivo validation of scaled-up, human-sized silk scaffold TEVG constructs seeded with extracellular vesicles. This...
This $241,823 federal Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) supports the development of an implantable engineered tissue with optogenetically engineered human beta-cells. The project aims to address challenges in creating vascularized tissues with light-activatable cells to improve treatment for diabetes. Key activities include designing a gelatin-based engineered tissue with oxygen-generating microparticles and optogenetically...
This is a Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The $200,000 award was granted to the University of North Carolina at Chapel Hill to study the effects of Nrf2 activation on vascular smooth muscle cell phenotype and arteriovenous fistula (AVF) stenosis in a mouse model, with the goal of improving AVF maturation and reducing...
This $700,619 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) aims to study and control rhythmic nephron formation for the development of functional kidney replacement tissues.
The research objectives are to: 1) determine the coordination of pace-making mechanisms across cell types in the mouse nephrogenic niche, and 2) synthetically engineer...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to investigate the relationship between cellular metabolism, inflammatory signaling, and epigenetic regulation in the context of vascular regeneration and cell transdifferentiation. The $1,245,515.38 award to The Methodist Hospital Research Institute Division aims to determine the molecular metabolic pathways that facilitate the...
This Project Grant award of $499,890.00 was issued by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The funding will support the development and evaluation of a novel therapy by Pavaj Vascular Corporation to prevent venous stenosis and improve arteriovenous fistula (AVF) function in patients with end-stage kidney disease requiring hemodialysis.
The key products and...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $696,870.00 to Boston Children's Hospital to conduct research on the endothelial cell niche for hematopoietic stem cells. The research aims to examine how vascular reprogramming can provide an alternative location for hematopoietic stem cell formation during stress or disease,...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $543,268 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the Beckman Research Institute of the City of Hope. This grant aims to elucidate the RNA-mediated epigenetic and epitranscriptional mechanisms underlying diabetes-associated endotheliopathy, in order to develop novel therapeutics to ameliorate diabetic vasculopathy.
The research will be conducted across three interconnected projects: 1)...
This Project Grant award from the National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems (CFDA 47.041 - Engineering) supports a $320,155 research project at Purdue University to investigate the complex flow and transport processes within microvascular networks and their impact on vascular remodeling.
The key objectives are to develop a novel computational model integrated with high-resolution imaging data to gain fundamental understanding...
This $659,199 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research on the biology and therapeutic potential of the growth differentiation factor 15 (GDF15) signaling pathway. The University of Pittsburgh, the primary awardee, will investigate novel mechanisms by which hepatocyte-derived GDF15 can improve obesity-associated insulin...