The Trustees of the University of Pennsylvania, through its Clinical Practices, was awarded a $243,750 Project Grant (R21DK142089) from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports the development of novel methods to improve detection of mosaic chromosomal alterations (MCA) in non-neoplastic tissues such as the kidney and blood. The research aims to enable new lines of inquiry into how MCA, which are associated with aging and various diseases, may exert tissue-specific effects. The project will involve creating single-cell sequencing methods and algorithms to localize MCA in spatial transcriptomics datasets, as well as designing high-throughput assays to evaluate MCA burden. All resulting protocols and software will be released as open-source to benefit the broader research community.
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