The University of Rochester received a $454,155 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to define the mechanisms by which the S100A4 protein modulates the formation and recurrence of post-operative abdominal adhesions, a leading cause of small bowel obstructions and other surgical complications. The project aims to leverage a mouse model to comprehensively map the molecular pathways underlying adhesion formation, delineate cell-type specific roles for S100A4, and evaluate the potential of short-term S100A4 inhibition to prevent or resolve mature adhesions. Findings from this research are expected to provide critical insights into the fundamental biology of adhesion development and identify new therapeutic approaches to address this significant clinical challenge.
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