The U.S. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $243,750 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Trustees of the University of Pennsylvania. The grant will fund the development of novel methods to improve detection of mosaic chromosomal alterations (MCA) in non-neoplastic tissues like the kidney and blood. The project aims to create single-cell sequencing techniques and spatial...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $434,950 to The Research Foundation For The State University Of New York to develop a microfluidic device that models the complex structure and selective filtration function of the kidney's glomerulus and Bowman's capsule. This "Glomerular-Bowman's Capsule System on a Chip" will...
This $400,000 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to understand the earliest events in podocyte injury in collagen IV nephropathies. The goal is to investigate how processing of mutant collagen IV proteins injures podocytes at early stages, leading to chronic kidney disease and renal failure. The research uses...
This $820,119 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research focused on elucidating the mechanobiological functions of novel cytoskeletal structures in podocytes to reveal new therapeutic opportunities for kidney glomerular diseases. The primary research aims to better understand the mechanisms underlying podocyte homeostasis,...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $223,918 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of Oklahoma Health Sciences Center. The purpose of this 20-month grant, awarded on September 28, 2024, is to study niche filling as a means to achieve long-term, kidney-specific depletion of resident macrophages in order to slow the progression of autosomal dominant polycystic...
The federal Project Grant award R01DK140070, in the amount of $700,619, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research (CFDA 93.847) program. The goal of this 4-year award is to study and control rhythmic nephron induction for kidney replacement tissues. The research aims to gain temporal control over rhythmic nephron formation in human induced pluripotent stem cell-derived kidney...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $168,886.00 to The University of Texas Southwestern Medical Center (UT Southwestern) to conduct research titled "Elucidating the Role of NAD+ and PARylation in Nephron Endowment." The award aims to study how maternal availability of nicotinamide adenine dinucleotide...
This $194,380 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to study the role of the protein LIM-nebulette in helping podocytes (kidney cells) adapt to mechanical stress, such as that caused by severe hypertension. The grantee, Icahn School of Medicine at Mount Sinai, will use a novel mechanical stretch platform and high-content image analysis to understand how...
This $675,480 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to develop a novel therapeutic compound for treating chronic kidney disease (CKD). The awardee, Fibrotherapeutics Inc., is conducting preclinical studies to evaluate the efficacy, safety, and therapeutic index of a modified, water-soluble, orally-active peptide derived...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $108,000 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Regents of the University of Michigan. The grant, titled "MICHIGAN SUMMER UNDERGRADUATE RESEARCH EXPERIENCE: DIABETES & METABOLIC DISEASES", will provide a 5-year summer research experience for 14 undergraduate students per year to instill an appreciation and passion for...