Project Grant R21DE036332
Award Date 9/1/26
Completion Date 8/31/28
Dollars Obligated $444K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Durham, NC 27710, USA
Similar Awards
- The National Institute of Dental and Craniofacial Research awarded $310,274 to the University of North Carolina at Chapel Hill on August 28, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121). The award funds a multidimensional phenotyping study characterizing the molecular, sensory, and psychosocial factors underlying comorbid temporomandibular disorder and migraine in adolescents. The project recruits 140 youth aged 10 to 17 years with TMD myalgia, stratified by the...
- The National Institute of Dental and Craniofacial Research awarded the University of Rochester $111,828 on January 8, 2027, under the Oral Diseases and Disorders Research program (CFDA 93.121) to fund fellowship training in neural circuit research related to temporomandibular joint disorder. The project investigates central nervous system dysfunction underlying temporomandibular joint disorder pathophysiology, specifically testing the hypothesis that alterations in amygdala-brainstem circuitry...
- The National Institute of Dental and Craniofacial Research awarded The Ohio State University $315,000 on July 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate autonomic dysfunction as a pathophysiological driver of multisystem temporomandibular disorders and to develop a clinical screening tool for early identification of high-risk individuals. The project addresses temporomandibular disorders (TMD) that affect over 12 million U.S. adults, particularly...
- The National Institute of Dental and Craniofacial Research awarded the Regents of the University of Minnesota $308,000 on August 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate DNA methylation signatures as clinical biomarkers in temporomandibular disorders and chronic pain conditions. The project addresses clinical heterogeneity in temporomandibular disorders (TMDs), where patients reporting identical pain intensity exhibit dramatically different...
- The National Institute of Dental and Craniofacial Research awarded the University of Washington $623,593 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the role of P75 neurotrophin receptor (P75NTR) in temporomandibular joint (TMJ) cartilage homeostasis and degenerative disease. The research defines cellular and molecular mechanisms regulating TMJ cartilage health and degeneration, with the goal of developing novel therapeutic strategies...
- The National Institute of Dental and Craniofacial Research awarded The University of Texas Health Science Center at San Antonio $433,125 on August 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate neuronal-glial coupling mechanisms in temporomandibular joint pain. The project examines the role of connexin 43, a gap junction protein expressed in satellite glial cells, in modulating trigeminal ganglion neuron-glia communication and pain processing in...
- Federal Grant Award Summary The University of North Carolina at Chapel Hill received a $310,295 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded on September 11, 2025, with a completion date of September 10, 2027. This research initiative aims to identify distinct subgroups of adolescents with chronic temporomandibular disorder (TMD) pain based on clinically relevant features...
- The National Institute of Dental and Craniofacial Research awarded Colorado State University $659,747 on June 18, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to characterize the biomechanical environment of the temporomandibular joint and develop an artificial TMJ disc replacement. The research addresses advanced temporomandibular joint disorders unresponsive to conservative treatment. Current surgical practice removes the diseased disc, but this disrupts joint...
- The National Institute of Dental and Craniofacial Research awarded the University of Pittsburgh a cooperative agreement worth $8,154,330 on September 9, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to establish the Collaborative for Research to Advance TMD Evidence (CREATE), a multi-site research initiative addressing temporomandibular disorders through integrated clinical and preclinical research. CREATE operates three functional cores plus a central longitudinal...
- The National Institute of Dental and Craniofacial Research awarded the ADA Forsyth Institute, Inc. (doing business as The Forsyth Institute) $706,281 on May 5, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate microRNA-mediated mechanisms in temporomandibular joint health and disease. The research examines how microRNAs regulate fibrocartilage stem and progenitor cells and the Hippo signaling pathway to maintain temporomandibular joint (TMJ) health and...