Project Grant R03DE036068
- The National Institute of Dental and Craniofacial Research awarded Duke University $444,125 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate central nervous system and autonomic correlates of temporomandibular disorder pain. The research characterizes how altered brainstem circuit activity and brain glymphatic flow relate to autonomic dysfunction in patients with chronic painful temporomandibular disorder (TMD). The project measures...
- The National Institute of Dental and Craniofacial Research awarded $310,274 to the University of North Carolina at Chapel Hill on August 28, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121). The award funds a multidimensional phenotyping study characterizing the molecular, sensory, and psychosocial factors underlying comorbid temporomandibular disorder and migraine in adolescents. The project recruits 140 youth aged 10 to 17 years with TMD myalgia, stratified by the...
- The National Institute of Dental and Craniofacial Research awarded the Regents of the University of Minnesota $405,911 on July 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to support the Minnesota Dental, Oral and Craniofacial Training in Research (MN-DOCTR) T32 Project Grant. The award funds a five-year trainee support program designed to educate the next generation of independent investigators in craniofacial, oral health, and dental research. The University of...
- The National Institute of Dental and Craniofacial Research awarded the University of Rochester $111,828 on January 8, 2027, under the Oral Diseases and Disorders Research program (CFDA 93.121) to fund fellowship training in neural circuit research related to temporomandibular joint disorder. The project investigates central nervous system dysfunction underlying temporomandibular joint disorder pathophysiology, specifically testing the hypothesis that alterations in amygdala-brainstem circuitry...
- The National Institute of Dental and Craniofacial Research, an operating division of the Department of Health and Human Services National Institutes of Health, awarded Regents of the University of Michigan $600,214 on August 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to define the neuronal basis of odontogenic pain and identify targets for non-opioid analgesic development. The project, led by Dr. Joshua Emrick, investigates the cells, circuits, and behavioral...
- The National Institute of Dental and Craniofacial Research awarded The Ohio State University $315,000 on July 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate autonomic dysfunction as a pathophysiological driver of multisystem temporomandibular disorders and to develop a clinical screening tool for early identification of high-risk individuals. The project addresses temporomandibular disorders (TMD) that affect over 12 million U.S. adults, particularly...
- The National Institute of Dental and Craniofacial Research awarded the Regents of the University of Minnesota $1.947 million on June 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate how the pioneer oral bacterium Streptococcus gordonii recognizes and responds to other early dental plaque colonizers and host factors, shaping initial biofilm community structure. The research examines the outside-in signaling circuit through which S. gordonii...
- The National Institute of Dental and Craniofacial Research awarded Massachusetts General Hospital $408,951 on February 15, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121, R21DE034917) to investigate photochemical tissue passivation as a treatment approach for temporomandibular joint osteoarthritis. The research applies photocrosslinking of tissue proteins—specifically collagen—through rose bengal solution and green light exposure to reduce inflammation and prevent...
- The National Institute of Dental and Craniofacial Research awarded the University of Washington $623,593 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the role of P75 neurotrophin receptor (P75NTR) in temporomandibular joint (TMJ) cartilage homeostasis and degenerative disease. The research defines cellular and molecular mechanisms regulating TMJ cartilage health and degeneration, with the goal of developing novel therapeutic strategies...
- The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health under the Department of Health and Human Services, awarded the University of Maryland, Baltimore $4.929 million on September 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop and validate a multi-omic, psychosocial, and environmental model of individual differences in pain and placebo responses. The project investigates chronic pain conditions, particularly...
The National Institute of Dental and Craniofacial Research awarded the Regents of the University of Minnesota $308,000 on August 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate DNA methylation signatures as clinical biomarkers in temporomandibular disorders and chronic pain conditions. The project addresses clinical heterogeneity in temporomandibular disorders (TMDs), where patients reporting identical pain intensity exhibit dramatically different functional limitations. At least 4 million of the 11.5 million individuals with TMDs in the United States meet high-impact chronic pain criteria, generating $12 billion in annual direct and indirect healthcare expenses. Current one-size-fits-all treatment approaches fail to account for this heterogeneity. The research tests the hypothesis that DNA methylation patterns can reflect both distinct and shared pathways across chronic pain conditions underlying heterogeneity in TMDs, offering opportunities for objective patient stratification and personalized treatments. DNA methylation offers particular advantages for clinical translation due to its stability, accessibility, and cost-effectiveness. Performance occurs at Minneapolis, Minnesota, with a period of performance from August 1, 2026, through July 31, 2028. The assistance type is a Project Grant, a mechanism under which NIDCR supports basic, translational, and clinical research in dental, oral, and craniofacial health and disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $308.0k | 8/4/26 |