Project Grant R01DE035223
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded The Children's Hospital of Philadelphia Research Institute a $507,006 Project Grant on August 1, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the role of hyaluronan in YAP (Yes-associated protein) signaling on temporomandibular joint (TMJ) health and pathology. The research will be conducted over a two-year period through July 31, 2027, and focuses...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded The Trustees of Columbia University in the City of New York a Project Grant of $655,455 under the Oral Diseases and Disorders Research program (CFDA 93.121) for research titled "Defining TMJ Cartilage Progenitors and Their Regulatory Niche for TMJ Regeneration." The award, effective September 11, 2025, with completion targeted for September 10, 2027, supports investigator-initiated...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded The Trustees of Columbia University in the City of New York a $1.48 million Project Grant on August 1, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) for development and validation of a patient-specific temporomandibular joint-on-a-chip (TMJ-OC) model. The award, with completion targeted for April 30, 2030, funds research to investigate multi-tissue crosstalk...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded Massachusetts General Hospital a Project Grant of $408,951 under the Oral Diseases and Disorders Research program (CFDA 93.121) on February 15, 2026, with completion scheduled for February 14, 2028. The award funds research and development of Photochemical Tissue Passivation (PTP), an innovative therapeutic approach designed to prevent the progression of temporomandibular joint osteoarthritis...
- This Project Grant award of $419,379, funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports fundamental and translational research into the molecular mechanisms by which Notch signaling regulates temporomandibular joint (TMJ) osteoarthritis. The research is designed to advance understanding of how alterations in cellular signaling pathways contribute to cartilage and bone degeneration in the...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded $398,000 to The Forsyth Institute under the Oral Diseases and Disorders Research program (CFDA 93.121) on July 15, 2025, for a two-year project grant concluding July 14, 2027. The research initiative investigates the mechanistic interactions between three bacterial species—Fusobacterium nucleatum, Actinomyces odontolyticus, and Nanosynbacter lyticus (TM7)—and their collective role in...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a Project Grant of $599,564 to the Regents of the University of Minnesota, with an award date of July 15, 2025 and completion date of July 14, 2027, under the Oral Diseases and Disorders Research program (CFDA 93.121). This grant funds the development and validation of a novel Jaw Metabolic Stressor (JMS) task designed to assess jaw muscle metabolic stress and brain functional characteristics related to jaw pain...
- Federal Project Grant Award Summary The University of Delaware received a $350,000 Project Grant awarded on September 4, 2025, from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859). The award funds a research project titled "Cellular Heterogeneity and Niche Regulation in TMJ" extending through May 31, 2030. This project addresses temporomandibular joint osteoarthritis (TMJ-OA), a degenerative joint disease...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded The Johns Hopkins University a $521,362 Project Grant on August 12, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate neuroimmune interactions in craniofacial bone healing. The research project, which extends through August 11, 2027, seeks to decode the signaling mechanisms between nerves, immune cells, and bone-forming cells during cranial bone repair....
- Federal Grant Award Summary Award Details: The National Institute of Dental and Craniofacial Research (NIDCR) awarded Augusta University Research Institute, Inc. a Project Grant totaling $645,009 under the Oral Diseases and Disorders Research program (CFDA 93.121). The award period runs from June 15, 2025, through June 14, 2027. Research Scope: This grant funds a research project investigating the molecular mechanisms of alveolar bone loss in periodontitis through examination of...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded $706,281 to The Forsyth Institute on May 5, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to conduct fundamental research on microRNA-mediated mechanisms in temporomandibular joint (TMJ) health and disease. The project, extending through April 30, 2031, will investigate how microRNAs regulate fibrocartilage stem/progenitor cells and the Hippo signaling pathway within the mandibular condylar cartilage—a unique multi-layered structure combining characteristics of both articular and growth plate cartilage. This research addresses a significant gap in oral health science, as TMJ osteoarthritis affects 8-16% of the population but remains substantially under-researched relative to other joint diseases. The research deliverables will advance the understanding of cartilage maintenance and regeneration mechanisms critical to treating TMJ disease, with potential applications in developing personalized treatment strategies and restoring cartilage integrity in affected patients. The project leverages The Forsyth Institute's established expertise in advanced biomedical research methodologies, including molecular and cellular analysis techniques, to generate findings that could translate into improved prevention and treatment approaches for orofacial functions such as speaking, chewing, and swallowing.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $706.3k | 5/11/26 |