Project Grant F30DE036496

The National Institute of Dental and Craniofacial Research awarded the University of Rochester $111,828 on January 8, 2027, under the Oral Diseases and Disorders Research program (CFDA 93.121) to fund fellowship training in neural circuit research related to temporomandibular joint disorder.

The project investigates central nervous system dysfunction underlying temporomandibular joint disorder pathophysiology, specifically testing the hypothesis that alterations in amygdala-brainstem circuitry drive motor control dysregulation and pain amplification. The research employs a multimodal approach combining functional and structural neuroimaging with quantitative biomechanical assessment. Aim 1 characterizes bite force biomechanics in TMD patients versus matched controls, measuring maximum voluntary contraction, endurance, and pain thresholds using a custom-developed MRI-compatible hydraulic bite force device. Aim 2 investigates circuit dysfunction through baseline circuit architecture via diffusion tensor imaging and resting-state functional MRI, and task-based functional connectivity during bite force generation. The approach integrates controlled bite force generation mimicking daily activities with advanced neuroimaging techniques optimized for subcortical and brainstem regions.

Fellowship training occurs in Dr. Paul Geha's Pain and Perception Laboratory at the University of Rochester. Performance of work takes place in Rochester, New York. The period of performance runs from January 8, 2027, through August 15, 2030.