Project Grant R21DE035249
- The federal Project Grant award of $309,038, issued on August 8, 2025 by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports the development of a novel anti-infective therapy for treating periodontitis. The project aims to develop a first-in-class inhibitor of the "red complex" bacteria (P. gingivalis, T. forsythia, and T. denticola) that are considered the causative agents of periodontitis, a...
- This federal Project Grant award of $311,000.00 from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will be used by the University of Washington to conduct research to characterize the microbial and inflammatory state within distant clinically healthy tissues in patients with active periodontal disease. The research aims to increase understanding of how inflammation is triggered and maintained during the...
- This $515,926 Project Grant awarded by the National Science Foundation (NSF) Engineering program (CFDA 47.041) will fund research to develop an in vitro gingival (gum) tissue system to study the role of microbial communities on oral health and disease. The 5-year project, beginning June 1, 2024, will be conducted by the University of Massachusetts Lowell's Office of Research Administration-Lowell. The key objectives are: (1) developing and validating a microphysiological system to study oral...
- This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), provides $241,500.00 to support research focused on identifying diffusible small molecules that regulate the replication of the oral bacterium Porphyromonas gingivalis (Pg). The goal is to elucidate the mechanisms by which Pg, a late-stage colonizer linked to periodontitis and other systemic conditions, overcomes...
- This $762,432 Project Grant was awarded by the National Institute of Dental and Craniofacial Research (NIDCR), part of the U.S. Department of Health and Human Services, under the Oral Diseases and Disorders Research (CFDA 93.121) program. The grant was awarded to the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences), a non-profit research organization, to investigate the role of the CD73 enzyme in controlling inflammation and bone loss associated with...
- This Project Grant award, funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports a research project focused on investigating the biogenesis and localization of gingipains - critical virulence factors of the oral pathogen Porphyromonas gingivalis. The $358,823 grant, awarded to Loma Linda University, aims to expand the understanding of gingipains' hemagglutinating/adhesive properties and the...
- This federal Project Grant award for $442,750.00, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to systematically identify the drivers controlling interactions between the bacterium Fusobacterium nucleatum (FN) and oral squamous cell carcinoma. The research aims to: 1) identify tumor cell determinants of FN invasion and altered tumor cell viability, and 2) identify microbial...
- This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will provide $423,500.00 to Nova Southeastern University, Inc. to develop a humanized mouse model of periodontitis. The goal is to investigate the potential pathogenic role of the protein Semaphorin 4D expressed by human osteoclasts in the progression of periodontal disease. This advanced mouse model will allow researchers to...
- This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $446,875 to support research on the role of a novel G protein-coupled receptor, MRGPRX2, in the development of periodontal disease. The funded research aims to develop two humanized mouse models to study the contribution of MRGPRX2-expressing mast cells to Porphyromonas gingivalis-induced and ligature-induced...
- This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) provides $226,500 to investigate how oral bacterial pathogens affect aging-associated immune responses and whether inhibition of the inflammatory marker CD38 can alleviate inflammatory bone loss and aging-associated immune responses induced by oral pathogens. The project, conducted by the Medical University of South Carolina, aims...
This $442,750 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will fund a research project titled "A Pathomimetic Gingiva-on-a-Chip for Assessing Microbiota-Directed Anti-Inflammatory Therapeutics" at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The project aims to identify metabolites that can selectively enhance beneficial oral microbes (symbionts) to suppress disease-promoting microbes (pathobionts) as a targeted therapeutic approach for periodontitis, or severe gum disease. The award period is from August 14, 2025 to August 13, 2027. The research will utilize ex vivo human saliva cultures to screen for metabolites, such as nitrate and arbutin, that can inhibit pathobionts in a microbiota-dependent manner, with the goal of developing more targeted anti-inflammatory treatments for periodontitis.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $442.8k | 8/14/25 |