This federal Project Grant award of $248,999 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research on the role of CD4+ memory T cell subtypes in periodontal disease recurrence. The primary objectives are to: 1) identify the spatiotemporal development of CD4+ memory T cells in periodontal tissues, 2) elucidate the pathogenicity of periodontal disease-induced CD4+ memory T cell subtypes,...
This Project Grant award of $248,627 from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121) supports research to understand the role of T cell responses to the oral pathogen Aggregatibacter actinomycetemcomitans in the immunopathology of periodontal disease. The research aims to: 1) assess systemic T cell responses to this pathogen in human periodontal disease, and 2) determine the role of...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $762,432 Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) in Augusta, GA. The project, titled "Metabolic-Purinergic Fitness in Periodontal Health and Disease", aims to investigate the role of the enzyme CD73 in controlling inflammation and bone loss associated with periodontal disease. The...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $307,000 Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to the University of Florida to investigate the expression of cellular senescence markers in gingival tissues of individuals with type 2 diabetes and periodontal disease. The project aims to compare senescence markers in healthy and diseased gingival biopsies between individuals with and without type 2 diabetes, and to correlate senescence...
This Project Grant award of $588,952 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is focused on developing a bio-inspired scaffold called "PerioPatch" to regenerate Sharpey's fibers and periodontal tissues. The key objectives are to: 1) develop and optimize a tubular matrix to guide periodontal ligament (PDL) principal fiber formation, 2) rebuild the microenvironment for Sharpey's fiber...
This $515,926 Project Grant awarded by the National Science Foundation (NSF) Engineering program (CFDA 47.041) will fund research to develop an in vitro gingival (gum) tissue system to study the role of microbial communities on oral health and disease. The 5-year project, beginning June 1, 2024, will be conducted by the University of Massachusetts Lowell's Office of Research Administration-Lowell. The key objectives are: (1) developing and validating a microphysiological system to study oral...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop novel therapies for endogenous periodontal regeneration. The $1,705,144 award to the University of Pittsburgh will fund research to 1) identify specific cell surface markers to isolate and characterize human PRX1-expressing periodontal stem cells, 2) develop a strategy to harness these stem cells for complete...
This federal Project Grant award of $185,918 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will fund research to evaluate the impact of Medicaid coverage for treatment of periodontal disease on health outcomes for Medicaid beneficiaries. The project aims to assess the effect of periodontal disease treatment coverage on tooth loss, emergency department use for dental problems, oral healthcare costs,...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), provides $645,009 to the Augusta University Research Institute, Inc. to investigate the role of osteocyte NOD1 signaling in bone loss associated with periodontal disease. The key objectives are to: 1) determine if osteocytes use the NOD1 receptor to recognize periodontal pathogens and induce the bone resorption...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $432,209 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to the University of California, Los Angeles (UCLA) for a 2-year period starting on August 1, 2023. The funding supports research to investigate the role of the CXCL10-CXCR3 axis in the compounding effects of diabetes mellitus on periodontitis. Specifically, the research aims to further elucidate the role of CXCL10 in the...
This federal Project Grant award of $311,000.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) to the University of Washington. The goal of the project is to employ single-cell RNA sequencing to characterize the microbial and inflammatory state within clinically healthy tissues of patients with active periodontal disease. Specifically, the project aims to resolve key differential signaling pathways between healthy sites and gingivitis, as well as between gingivitis and periodontitis, by analyzing the activity of immune cell types involved in tissue degradation and bone resorption. The award has a project period from August 1, 2025 to July 31, 2027 and is expected to contribute to existing public resources on periodontal disease and expand current knowledge on maintaining healthy oral homeostasis, resolving inflammation, and preventing disease progression.