Project Grant R21DE034093
Award Date
4/1/25
Completion Date
3/31/27
Dollars Obligated
$242K
Federal Agency
National Institute of Dental and Craniofacial Research
Federal Grant Program
93.121
Assistance Type
Project Grant
Place of Performance
New York, USA
Similar Awards
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $858,000 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program to the University of Texas Health Science Center at Houston (UTHealth). The purpose of this 2-year award, with a start date of September 18, 2024, is to explore the mechanisms by which the anaerobic bacterium Veillonella inhibits the hemolytic activity of the periodontal pathogen Porphyromonas gingivalis (P....
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1,645,396 Project Grant to the ADA Forsyth Institute, Inc. (doing business as The Forsyth Institute) under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program. The research project aims to improve understanding of the molecular mechanisms controlling the synthesis of surface structures in the periodontal pathogen Porphyromonas gingivalis, which is strongly associated with adult periodontal...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $226,500.00 to The Medical University of South Carolina to conduct research on the role of CD38 signaling in aging-associated immune responses induced by oral bacterial pathogens. The goal is to determine if inhibiting CD38, an inflammatory marker, can attenuate periodontal inflammatory bone loss and alleviate...
This Project Grant award of $163,411 from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program supports research by The Ohio State University to investigate the interactions between health-associated and disease-associated oral bacteria in dental biofilms. The research aims to elucidate how these microbes partition nutritional niches and modify carbohydrate utilization preferences, with the long-term goal of...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $162,216 to The Forsyth Institute, a non-profit research organization, from June 10, 2024 to May 31, 2026.
The project aims to investigate microbe-microbe interactions in the oral microbiome at the single-cell level using a combination of expansion microscopy and multiplex FISH imaging. This will allow the...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $565,228 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to the University of Pittsburgh. The 5-year grant, running from August 2024 to May 2029, aims to 1) identify specific cell surface markers to isolate and characterize human periodontal ligament stem cells expressing the PRX1 transcription factor (hPRX1-PCs), 2) develop a novel strategy to harness these stem cells to induce...
This $446,875 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, supports research into the role of a novel G protein-coupled mast cell receptor, MRGPRX2, in the pathogenesis of periodontal disease. The project aims to develop humanized mouse models expressing the human MRGPRX2 receptor to study the contribution of mast cell recruitment and activation through this receptor...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $995,000.00 to the ADA Forsyth Institute, Inc. (doing business as The Forsyth Institute) to conduct research on the mechanisms of peroxisome proliferator-activated receptor-alpha (PPAR-α) regulation in periodontitis.
The research aims to determine if PPAR-α agonist treatment can modulate macrophage polarization...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the federal Oral Diseases and Disorders Research program (CFDA 93.121), provides $1,029,581 to Virginia Commonwealth University (VCU) to conduct research on the two-component signaling systems of the oral bacterium Treponema denticola. The research aims to elucidate how T. denticola's sensory systems enable it to thrive in the diseased periodontal environment and contribute to periodontitis...
This $656,315 Project Grant was awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The overarching goal is to mechanistically study the effect of biomaterial cyclic strain on the pathogenesis of oral microbes, focusing on the fungal strain Candida albicans and denture-related microbiota. The research will use common denture materials (Aim 1), hard oral mucosa (Aim 2), and an animal model (Aim 3)...