Project Grant R56DE034451
- The federal Project Grant award of $309,038, issued on August 8, 2025 by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports the development of a novel anti-infective therapy for treating periodontitis. The project aims to develop a first-in-class inhibitor of the "red complex" bacteria (P. gingivalis, T. forsythia, and T. denticola) that are considered the causative agents of periodontitis, a...
- This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), provides $241,500.00 to support research focused on identifying diffusible small molecules that regulate the replication of the oral bacterium Porphyromonas gingivalis (Pg). The goal is to elucidate the mechanisms by which Pg, a late-stage colonizer linked to periodontitis and other systemic conditions, overcomes...
- This $442,750 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will fund a research project titled "A Pathomimetic Gingiva-on-a-Chip for Assessing Microbiota-Directed Anti-Inflammatory Therapeutics" at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The project aims to identify metabolites that can selectively enhance beneficial oral...
- This federal Project Grant award of $311,000.00 from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will be used by the University of Washington to conduct research to characterize the microbial and inflammatory state within distant clinically healthy tissues in patients with active periodontal disease. The research aims to increase understanding of how inflammation is triggered and maintained during the...
- This $762,432 Project Grant was awarded by the National Institute of Dental and Craniofacial Research (NIDCR), part of the U.S. Department of Health and Human Services, under the Oral Diseases and Disorders Research (CFDA 93.121) program. The grant was awarded to the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences), a non-profit research organization, to investigate the role of the CD73 enzyme in controlling inflammation and bone loss associated with...
- This $431,750 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) supports research to decipher the mechanisms by which two proteins, AAFLP-1 and AADCUB, regulate the production of exopolysaccharide (PNAG) in the oral bacterium Aggregatibacter actinomycetemcomitans. The research aims to investigate how these two proteins, which are unique to A. actinomycetemcomitans, independently...
- This Project Grant award, totaling $645,009.00 and provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), aims to investigate the role of osteocytes and the nucleotide-binding oligomerization domain containing 1 (NOD1) receptor in the mechanism of alveolar bone loss associated with periodontal disease. The research, to be conducted by Augusta University Research Institute, Inc. (doing...
- This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $446,875 to support research on the role of a novel G protein-coupled receptor, MRGPRX2, in the development of periodontal disease. The funded research aims to develop two humanized mouse models to study the contribution of MRGPRX2-expressing mast cells to Porphyromonas gingivalis-induced and ligature-induced...
- This $385,116 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, supports research on senescent periodontal ligament cells as a potential therapeutic target for age-associated periodontitis. The award to Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) aims to investigate the mechanisms by which aging increases periodontal disease bone loss,...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $432,209 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to the University of California, Los Angeles (UCLA) for a 2-year period starting on August 1, 2023. The funding supports research to investigate the role of the CXCL10-CXCR3 axis in the compounding effects of diabetes mellitus on periodontitis. Specifically, the research aims to further elucidate the role of CXCL10 in the...
This Project Grant award, funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports a research project focused on investigating the biogenesis and localization of gingipains - critical virulence factors of the oral pathogen Porphyromonas gingivalis. The $358,823 grant, awarded to Loma Linda University, aims to expand the understanding of gingipains' hemagglutinating/adhesive properties and the formation of their surface complexes. The research project seeks to determine the post-translational processing steps leading to the assembly of gingipain complexes on the bacterial surface, as well as conduct comparative analyses of the proteolytic activity and biological functions of pro-gingipains and their native non-covalent complexes. This research is expected to contribute to the development of new therapeutic approaches for managing periodontitis, a prevalent and chronic oral disease linked to various systemic health conditions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $358.8k | 9/11/25 |