This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, supports comprehensive research focused on understanding, preventing, and treating periodontal diseases. The total funding amount is $557,606.00, awarded on April 16, 2025, with an ultimate completion date of March 31, 2030. The key objective of this project is to elucidate the cellular and molecular mechanisms...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $226,500 Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to The Medical University of South Carolina (MUSC) for the period of May 1, 2025 to April 30, 2027. The purpose of this grant is to investigate how oral bacterial pathogens influence aging-associated immune responses and determine if inhibition of the CD38 signaling pathway can attenuate inflammatory bone loss and alleviate aging-related...
This $248,999 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to investigate the role of CD4+ memory T cell subtypes in the recurrence of periodontal disease. The project aims to: 1) identify the spatiotemporal development of CD4+ memory T cells in periodontal tissues, 2) elucidate the pathogenicity of CD4+ memory T cell subtypes induced by periodontal disease,...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $432,209 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to the University of California, Los Angeles (UCLA) for a 2-year period starting on August 1, 2023. The funding supports research to investigate the role of the CXCL10-CXCR3 axis in the compounding effects of diabetes mellitus on periodontitis. Specifically, the research aims to further elucidate the role of CXCL10 in the...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $155,500 in funding to the University of Maryland, Baltimore from June 1, 2025 to May 31, 2027. The project aims to elucidate the functions of the enzyme ENPP1 and its role in regulating pyrophosphate levels, which are critical for proper mineralization processes in cementogenesis (the formation of cementum on tooth...
This $236,756 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research Program (CFDA 93.121) supports research to investigate the role of the lysine-specific demethylase 1 (LSD1) protein in regulating osteoclast activity and bone loss during periodontal disease. The key research activities include: 1) conducting an in-depth study of ligature-induced periodontitis in mandible-derived osteoclast precursors from...
This $241,500 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, will fund research to identify diffusible small molecules that regulate the replication of the oral bacterium Porphyromonas gingivalis. The key objectives are to establish the identity of growth-promoting cues produced by different strains of P. gingivalis and the early colonizer Veillonella parvula that support P....
This Project Grant award, valued at $350,000.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The funding will support a comprehensive research project to investigate how the bacterial second messenger cyclic di-3',5'-adenylic acid (c-di-AMP) regulates the structure and function of lipopolysaccharide (LPS) in the pathogenic bacterium Porphyromonas gingivalis. The research aims to characterize...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $995,000.00 to the ADA Forsyth Institute, Inc. (doing business as The Forsyth Institute) to conduct research on the mechanisms of peroxisome proliferator-activated receptor-alpha (PPAR-α) regulation in periodontitis. The research aims to determine if PPAR-α agonist treatment can modulate macrophage polarization to...
This $858,000 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to explore the mechanisms by which the anaerobic bacterium Veillonella inhibits the hemolytic activity of the oral pathogen Porphyromonas gingivalis. The research will investigate how Veillonella's heme production regulates P. gingivalis' interactions with the host immune system, with the goal of uncovering novel...