Project Grant R21DE033537
Award Date
9/4/24
Completion Date
9/3/26
Dollars Obligated
$447K
Federal Agency
National Institute of Dental and Craniofacial Research
Federal Grant Program
93.121
Assistance Type
Project Grant
Place of Performance
Philadelphia, PA 19104, USA
Similar Awards
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will provide $423,500.00 to Nova Southeastern University, Inc. to develop a humanized mouse model of periodontitis. The goal is to investigate the potential pathogenic role of the protein Semaphorin 4D expressed by human osteoclasts in the progression of periodontal disease. This advanced mouse model will allow researchers to...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121), provides $241,500.00 to The Research Foundation For The State University Of New York to identify diffusible small molecules that regulate the replication of the bacterium Porphyromonas gingivalis (P. gingivalis). The research aims to establish the identity of the growth-promoting cues produced by different strains of...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $858,000 to the University of Texas Health Science Center at Houston to investigate the role of the bacterium Veillonella in regulating the inflammatory effects of the oral pathogen Porphyromonas gingivalis. The key objectives are to: 1) explore the mechanisms by which Veillonella inhibits the hemolytic (red blood...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) provides $873,546 to develop an "oral micro-drug factory" using engineered Lactobacillus reuteri bacteria to locally deliver the anti-inflammatory cytokine interleukin-10 (IL-10) for treating periodontitis. The goals are to validate the ability of the engineered bacteria to treat experimental periodontitis and...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $995,000.00 to the ADA Forsyth Institute, Inc. (doing business as The Forsyth Institute) to conduct research on the mechanisms of peroxisome proliferator-activated receptor-alpha (PPAR-α) regulation in periodontitis. The research aims to determine if PPAR-α agonist treatment can modulate macrophage polarization to...
This $322,696 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, supports research to investigate the role of the NOD1 receptor in osteocytes as a mechanism for bone loss in periodontitis. The research aims to determine if osteocytes use NOD1 to recognize periodontal pathogens and induce RANKL expression, as well as assess whether deleting NOD1 in osteocytes protects against alveolar...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to investigate the role of T cell immune responses to the oral pathogen Aggregatibacter actinomycetemcomitans (AA) in the development of periodontal disease. The $248,627 award, effective from January 1, 2025 to December 31, 2029, will fund two primary research aims: 1) Assessing systemic T cell responses...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $226,500 Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to The Medical University of South Carolina (MUSC) to conduct research on the role of CD38 signaling in aging-associated immune responses induced by oral bacterial pathogens. The goal is to determine if inhibition of CD38 can attenuate inflammatory bone loss and alleviate aging-associated immune responses caused by oral pathogens like...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is focused on developing a novel antibody-based therapy to prevent alveolar bone loss in severe periodontitis. The award, totaling $304,019, will enable the prime awardee, Panorama Research Incorporated, to identify and evaluate a panel of human anti-human OC-STAMP monoclonal antibodies. The goal is to identify a lead antibody...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will fund research focused on understanding the role of CD4+ memory T cell subtypes in the recurrence of periodontal disease. The $248,999 award will be used to: 1) Identify the spatiotemporal development of CD4+ memory T cells in periodontal tissues, 2) Elucidate the pathogenic potential of CD4+ memory T cell subtypes in...