Project Grant R21DE034562
Award Date
7/1/25
Completion Date
6/30/27
Dollars Obligated
$429K
Federal Agency
National Institute of Dental and Craniofacial Research
Federal Grant Program
93.121
Assistance Type
Project Grant
Place of Performance
Alabama, USA
Similar Awards
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), provides $248,750.00 to the ADA Forsyth Institute, Inc. (The Forsyth Institute) to investigate the role of cellular senescence in salivary gland dysfunction associated with Sjögren's syndrome. The research aims to determine the impact of cellular senescence on Sjögren's syndrome-related xerostomia (dry mouth) and...
This federal Project Grant award of $1,386,899.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The grant aims to define how Sjögren's disease endotypes modify the immunobiology of salivary gland mesenchymal stromal cells, comparing mouse and human models. The research will use JAK inhibitors as immunopharmacological probes to determine the signaling pathways driving maladaptive mouse...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $714,711 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the Icahn School of Medicine at Mount Sinai. The 5-year grant, which commenced on July 1, 2025, aims to investigate mechanisms that can specifically protect or regenerate salivary glands without benefiting cancer growth following radiation therapy. The research team developed a scalable gene targeting system to screen over...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop microphysiological systems (MPSs) that can recapitulate the complex pathogenesis of Sjogren's disease (SjD), a systemic autoimmune condition affecting the salivary glands. The $196,459 award, effective from August 1, 2025 to July 31, 2027, will support research to investigate how collagen density and the presence...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to determine the function of TRP-positive trigeminal sensory neurons innervating the submandibular salivary glands. The $174,418 award to the Regents of the University of Michigan will support research to understand how this direct sensory innervation provides feedback to modulate the salivary system, with the goal of...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $491,193 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the University of California, San Diego (UCSD) for the project "Engineering Mucin Analogues to Benefit the Mouth Environment." The project aims to create advanced mucin substitutes that closely emulate the physiological functions of natural salivary mucins, in order to develop enhanced artificial saliva...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $231,492 to develop an in vitro salivary gland Sjogren's syndrome (SS) tissue chip (SSTC) platform. The goal is to use this SSTC platform to investigate the effects of endocrine-disrupting chemicals on the growth and function of salivary gland tissue mimetics. The project will also perform RNA sequencing studies...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is providing $409,960.00 to Texas A&M University System Health Science Center to develop a human salivary gland-on-a-chip model. The goal is to create a platform that can faithfully replicate normal salivary gland function as well as model the effects of radiation-induced damage, in order to improve drug development efforts...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $2,078,772 to Hydronovo, Inc. to conduct critical Investigational New Drug (IND)-enabling studies for their regenerative therapy CVGN8. CVGN8 is an injectable neuromimetic hydrogel that aims to restore salivary gland function in patients suffering from xerostomia (dry mouth), a condition often caused by radiation...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), is providing $100,676 to the Icahn School of Medicine at Mount Sinai to conduct research on defining the role of tissue-resident macrophages during salivary gland morphogenesis. The research aims to determine the functional contribution of these macrophages to salivary gland development and characterize their role in...