This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $628,965 to the Icahn School of Medicine at Mount Sinai to conduct research on immune-derived mediators that regulate salivary gland development and differentiation. The 5-year project aims to elucidate how immune cells, particularly tissue-resident macrophages, govern salivary gland epithelial cell processes and...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $608,632.33 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Research Foundation For The State University Of New York (RF SUNY). The award, effective September 1, 2024, supports a research project investigating the role of rare chemosensory epithelial cells known as "tuft cells" in salivary gland immunity. The project aims to utilize advanced microscopic techniques,...
This Project Grant award of $1,039,386 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports Hydronovo, Inc.'s development of CVGN8, an injectable neuromimetic hydrogel that aims to regenerate radiation-damaged salivary glands and restore function for patients suffering from xerostomia (dry mouth). The key objectives funded under this award are to: (1) conduct a GLP safety study in a second animal...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $3,001,833 to the University of Missouri System to conduct research on inhibiting radiation-induced salivary gland fibrosis by targeting copper metabolism. The research aims to elucidate the molecular mechanisms of altered copper homeostasis in irradiated salivary glands, evaluate the therapeutic potential of salivary...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $1,493,635 to Sinopia Biosciences Inc. to develop a novel oral compound for treating radiation-induced oral mucositis. The project aims to characterize a selectively-inhibiting compound that demonstrated compelling results in preclinical studies, with the goal of advancing it towards clinical trials. Oral mucositis is a...
This federal Project Grant award of $533,675.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research aimed at improving bone regeneration and modulating cellular senescence in radiation-damaged jawbones. The awardee, Trustees of Dartmouth College, will develop a combined 3D-printed mineral scaffold and cryogel construct to enhance bone formation and mitigate the detrimental effects...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $115,992 to The Research Foundation For The State University Of New York (RF SUNY) to develop human induced pluripotent stem cell (iPSC)-derived salivary gland organoids (SGOs) with secretory function and well-defined architecture. The project aims to utilize engineered viscoelastic hydrogels to optimize the...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $231,492 to develop an in vitro salivary gland Sjogren's syndrome (SS) tissue chip (SSTC) platform. The goal is to use this SSTC platform to investigate the effects of endocrine-disrupting chemicals on the growth and function of salivary gland tissue mimetics. The project will also perform RNA sequencing studies...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is providing $130,303 to the Regents of the University of Michigan to conduct research on the function of TRP-positive trigeminal sensory neurons innervating the submandibular salivary glands. The objectives are to determine the central and peripheral targets of these neurons and how they respond to chemical stimuli to modulate...
This federal Project Grant award of $339,000 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The funding supports research by New York University School of Medicine to investigate the role of autocrine cholinergic signaling in maintaining memory T cell responses in oral squamous cell carcinoma. The research project will be conducted from August 1, 2024 to July 31, 2026. As a leading...