This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $714,711 to the Icahn School of Medicine at Mount Sinai to study mechanisms for protecting and regenerating salivary glands after radiation therapy. The key focus is on identifying genetic targets, such as SMARCA2 depletion, that can specifically promote salivary epithelium growth without also benefiting cancer growth....
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $115,992 to The Research Foundation For The State University Of New York (RF SUNY) to develop human induced pluripotent stem cell (iPSC)-derived salivary gland organoids (SGOs) with secretory function and well-defined architecture. The project aims to utilize engineered viscoelastic hydrogels to optimize the...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $1,493,635 to Sinopia Biosciences Inc. to develop a novel oral compound for treating radiation-induced oral mucositis. The project aims to characterize a selectively-inhibiting compound that demonstrated compelling results in preclinical studies, with the goal of advancing it towards clinical trials. Oral mucositis is a...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $491,193 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the University of California, San Diego (UCSD) for the project "Engineering Mucin Analogues to Benefit the Mouth Environment." The project aims to create advanced mucin substitutes that closely emulate the physiological functions of natural salivary mucins, in order to develop enhanced artificial saliva...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is providing $130,303 to the Regents of the University of Michigan to conduct research on the function of TRP-positive trigeminal sensory neurons innervating the submandibular salivary glands. The objectives are to determine the central and peripheral targets of these neurons and how they respond to chemical stimuli to modulate...
This federal Project Grant award of $533,675.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research aimed at improving bone regeneration and modulating cellular senescence in radiation-damaged jawbones. The awardee, Trustees of Dartmouth College, will develop a combined 3D-printed mineral scaffold and cryogel construct to enhance bone formation and mitigate the detrimental effects...
The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded a $976,000 Project Grant (Award ID: R44DE035026) to Matregenix Inc., a minority-owned small disadvantaged business in California. The grant supports the development of MATRINOVA, an animal-free, amino acid-based biodegradable barrier membrane for guided bone regeneration in dental and craniomaxillofacial surgeries. Key objectives include assessing...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $3,001,833 to the University of Missouri System to conduct research on inhibiting radiation-induced salivary gland fibrosis by targeting copper metabolism. The research aims to elucidate the molecular mechanisms of altered copper homeostasis in irradiated salivary glands, evaluate the therapeutic potential of salivary...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $628,965 to the Icahn School of Medicine at Mount Sinai to conduct research on immune-derived mediators that regulate salivary gland development and differentiation. The 5-year project aims to elucidate how immune cells, particularly tissue-resident macrophages, govern salivary gland epithelial cell processes and...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $231,492 to develop an in vitro salivary gland Sjogren's syndrome (SS) tissue chip (SSTC) platform. The goal is to use this SSTC platform to investigate the effects of endocrine-disrupting chemicals on the growth and function of salivary gland tissue mimetics. The project will also perform RNA sequencing studies...