This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, supports comprehensive research focused on understanding, preventing, and treating periodontal diseases. The total funding amount is $557,606.00, awarded on April 16, 2025, with an ultimate completion date of March 31, 2030. The key objective of this project is to elucidate the cellular and molecular mechanisms...
This $1,705,144 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop novel therapies for endogenous periodontal regeneration. The key objectives are: 1) identifying specific cell surface markers to isolate and characterize human PRX1-expressing periodontal ligament stem cells (hPRX1-PCs), 2) developing a strategy to harness these stem cells to induce complete...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop a bio-inspired scaffold (PeriopatchTM) for regenerating Sharpey's fibers and periodontal tissues. The $588,952 award will fund research to integrate crucial biophysical and biochemical cues into a matrix that can guide periodontal ligament stem cell migration, growth, and formation of well-aligned principal...
This $248,999 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to investigate the role of CD4+ memory T cell subtypes in the recurrence of periodontal disease. The project aims to: 1) identify the spatiotemporal development of CD4+ memory T cells in periodontal tissues, 2) elucidate the pathogenicity of CD4+ memory T cell subtypes induced by periodontal disease,...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $381,216 to conduct research on the role of the ectonucleotidase CD73 in periodontal health and disease. The research aims to delineate how CD73 deficiency leads to metabolic dysfunction and inflammation in gingival fibroblasts, and study how this impacts the stromal-osteoclast axis and influences periodontal...
This $236,756 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research Program (CFDA 93.121) supports research to investigate the role of the lysine-specific demethylase 1 (LSD1) protein in regulating osteoclast activity and bone loss during periodontal disease. The key research activities include: 1) conducting an in-depth study of ligature-induced periodontitis in mandible-derived osteoclast precursors from...
This $241,500 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, will fund research to identify diffusible small molecules that regulate the replication of the oral bacterium Porphyromonas gingivalis. The key objectives are to establish the identity of growth-promoting cues produced by different strains of P. gingivalis and the early colonizer Veillonella parvula that support P....
The Project Grant award R43DE033577, with a total funding of $304,019, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121). The award is for the development of a novel antibody-based therapy to prevent alveolar bone loss in severe periodontitis, a leading cause of tooth loss. The project, conducted by Panorama Research Incorporated, aims to identify and evaluate a panel of human...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is focused on developing bioengineered 3D tooth germs for tooth regeneration. The $443,576 award will support research to regulate the self-renewal and differentiation of human induced pluripotent stem cells (hiPSCs) into odontogenic epithelial stem cells (OESCs) and neural crest cells (NCCs), and co-culture these stem...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $432,209 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to the University of California, Los Angeles (UCLA) for a 2-year period starting on August 1, 2023. The funding supports research to investigate the role of the CXCL10-CXCR3 axis in the compounding effects of diabetes mellitus on periodontitis. Specifically, the research aims to further elucidate the role of CXCL10 in the...