Project Grant R01DE034978

Award Date 4/18/25
Completion Date 3/31/30
Dollars Obligated $589K
Federal Grant Program
93.121
Assistance Type
Project Grant
Place of Performance
Columbia, MO 65211, USA
Similar Awards
This Project Grant award of $565,228, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program, aims to identify cell surface markers and develop strategies for harnessing periodontal ligament stem cells (PDLSCs) to induce endogenous periodontal regeneration. The research, conducted by the University of Pittsburgh from August 2024 to May 2029, seeks to characterize the human homologs of mouse...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), totaling $557,606.00, supports research aimed at advancing the understanding of periodontal stem cells and their regulation for more predictable and efficient periodontal tissue regeneration. The key research objectives are to: 1) characterize the properties of periodontal crestal stem cells (PCSCs) and their activation by...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $873,546 Project Grant under the Oral Diseases and Disorders Research Program (CFDA 93.121) to the University of Texas Health Science Center at Houston (UTHealth). The grant aims to develop a biomaterial-enhanced system for targeted localization of engineered probiotic bacteria (Limosilactobacillus reuteri) that secrete the anti-inflammatory cytokine interleukin-10 (IL-10) to treat experimental periodontitis. The key...
The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121), awarded a $306,499 Project Grant to Oridivus LLC to develop an innovative oral regenerative therapy for improving wound healing in the oral cavity. The funding will be used to optimize and compare the immunoregenerative efficacy of an FTY720 nanofiber (FTY720-NF) scaffold versus platelet-rich plasma (PRP) in rodent and porcine animal models....
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $398,785 to Regendodent, Inc. to further develop REGENDOGEL (RG), a novel dental material that stimulates regeneration of dental pulp and dentin. RG is being advanced as a replacement for non-degradable silicate cements currently used in vital pulp therapy and endodontic root canal procedures. The funding will be used...
The National Institute of Dental and Craniofacial Research (NIDCR), part of the Department of Health and Human Services, awarded a $847,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the University of Utah. The 2-year grant, awarded on August 1, 2023, will fund research to develop and evaluate the efficacy of a novel antimicrobial bone scaffold made from zinc-doped fluorapatite for use in craniofacial surgical applications. The research aims to...
This $675,684 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will fund a two-year research project at the University of Michigan to investigate the microbial ecosystem and host interactions around dental implants. The goal is to improve understanding of how this ecosystem develops, becomes unbalanced, and leads to peri-implantitis, a common inflammatory condition that...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $161,762 in funding to the University of Illinois to conduct research on the role of the proteoglycan NG2/CSPG4 in endochondral fracture healing of the mandible. The research plan utilizes a preclinical murine model and transgenic knockout animal models to define the specific molecular pathways by which mechanical...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $294,000 over a 2-year period from September 2024 to September 2026. The objective is to advance the understanding of craniofacial cartilage differentiation from human neural crest stem cells in 3D cell culture models. The research aims to develop methods for generating functional, transplantable craniofacial cartilage...
This $800,000 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to elucidate the role of matrix metalloproteinase 13 (MMP13) in regulating the dental pulp's reparative processes and inflammatory response. The key objectives are to determine how MMP13 influences tertiary dentin formation and modulates the immunological response in pulpitis, as well as to translate...

This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) totals $588,952 and will run from April 2025 to March 2030. The funding will support the development and optimization of a bio-inspired tubular matrix scaffold to guide the formation of periodontal ligament (PDL) principal fibers and rebuild the microenvironment for the regeneration of Sharpey's fibers, which are critical for functional PDL and alveolar bone integration. The research aims to address a major challenge in periodontal tissue regeneration and advance regenerative periodontal therapy. The work will be conducted by the University of Missouri System, a comprehensive public research university with extensive expertise in healthcare, engineering, and scientific research.

Generated 4/29/25, 4:01 AM