The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $435,167 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Research Foundation For The State University Of New York (RF SUNY) for the project "DEVELOPMENT OF AN EARLY TOOTH ORGANOID VIA HUMAN INDUCED PLURIPOTENT STEM CELLS". The project aims to use human induced pluripotent stem cells (iPSCs) to derive clinically-relevant dental cell types and develop a robust human...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $157,500 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Ohio State University to conduct research on the cellular mechanisms regulating tooth development. The research aims to determine how the signaling molecule SEMA7A influences the mineralization of dentin, elongation of tooth roots, and innervation of teeth. The study will use global and conditional SEMA7A knockout mouse...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, provides $1,849,232.90 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to identify the cellular and molecular identity of genes and pathways defining dental mesenchymal cell differentiation and fate early in tooth development. The goal is to harness this information to develop potential...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $697,288 to Texas A&M University System Health Science Center to conduct research on a novel GTPase regulator that governs the regenerative capacity of murine (mouse) teeth. The research aims to: 1) determine the role of this regulator, called DIN, and the cell fate of DIN-positive versus DIN-negative...
This federal Project Grant award, valued at $294,000 and spanning September 2024 to September 2026, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The grant supports research to understand the mechanisms of craniofacial cartilage differentiation from human neural crest stem cells, with the goal of developing tissue engineering approaches to repair birth defects and injuries to the head and...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop novel therapies for endogenous periodontal regeneration. The $1,705,144 award to the University of Pittsburgh will fund research to 1) identify specific cell surface markers to isolate and characterize human PRX1-expressing periodontal stem cells, 2) develop a strategy to harness these stem cells for complete...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will provide $295,600 to The University of British Columbia (UBC) to gain fundamental insights into the process of tooth generation and loss using the innovative leopard gecko model. The key products and services to be delivered under this 24-month award include pioneering experiments to better understand the mechanisms behind...
This federal Project Grant award of $503,648 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to investigate the genetic mechanisms driving the specification of oral/dental and skin lineages in the mandibular ectoderm. The research aims to determine how transcription factor interactions regulate these epithelial patterning processes, including identifying the chromatin-level regulation...
This Project Grant award of $408,375 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will fund research on a novel biomimetic nitric oxide and hydroxyapatite (NO-HA) duo for advanced direct pulp capping. The research aims to develop a synergistic solution that can enhance bioactive and physical-mechanical barrier functions to support pulp-dentin repair and preserve tooth vitality. Key objectives...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1,196,355 Project Grant (CFDA 93.121 Oral Diseases and Disorders Research) to Regendodent, Inc. in Ann Arbor, Michigan. The grant will support the development of REGENDOGEL (RG), a new class of dental material that stimulates regeneration of dental pulp and dentin damaged by decay or trauma. The project aims to compare the original RG formulation using bovine-derived dentin matrix molecules (DMMs) with a new...