This Project Grant award of $588,952 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is focused on developing a bio-inspired scaffold called "PerioPatch" to regenerate Sharpey's fibers and periodontal tissues. The key objectives are to: 1) develop and optimize a tubular matrix to guide periodontal ligament (PDL) principal fiber formation, 2) rebuild the microenvironment for Sharpey's fiber...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program provides $456,500.00 to the University of Southern California (USC) to conduct research on periodontal tissue regeneration. The key focus is to investigate the use of a supramolecular nanomaterial called peptide amphiphile (PA) to enhance the regenerative effects of the bioactive peptide leucine-rich amelogenin peptide...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $557,606 to President and Fellows of Harvard College, doing business as Harvard Medical School, to conduct research focused on cellular and molecular control of periodontal tissue regeneration. The research aims to characterize periodontal crestal stem cells, determine signaling pathways regulating their activation and...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $304,019 to Panorama Research Incorporated to identify and evaluate a panel of human anti-human OC-STAMP monoclonal antibodies. The goal is to develop a novel therapeutic to slow or halt the loss of alveolar bone and teeth in severe periodontitis. The research will utilize a ligature-induced periodontitis model in a human...
This federal Project Grant award of $311,000.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) to the University of Washington. The goal of the project is to employ single-cell RNA sequencing to characterize the microbial and inflammatory state within clinically healthy tissues of patients with active periodontal disease. Specifically, the project aims to resolve key differential signaling...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $762,432 Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) in Augusta, GA. The project, titled "Metabolic-Purinergic Fitness in Periodontal Health and Disease", aims to investigate the role of the enzyme CD73 in controlling inflammation and bone loss associated with periodontal disease. The...
This federal Project Grant award of $248,999 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research on the role of CD4+ memory T cell subtypes in periodontal disease recurrence. The primary objectives are to: 1) identify the spatiotemporal development of CD4+ memory T cells in periodontal tissues, 2) elucidate the pathogenicity of periodontal disease-induced CD4+ memory T cell subtypes,...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $873,546 to the University of Texas Health Science Center at Houston to develop an "oral micro-drug factory" using engineered Limosilactobacillus reuteri bacteria to secrete the anti-inflammatory cytokine interleukin-10 (IL-10) for treating periodontitis. The goal is to locally administer the...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is focused on developing an off-the-shelf biomaterial that can regenerate craniofacial bone defects of any shape or size. The $300,155 award to Colorado State University aims to evaluate the osteoinductivity of recently identified peptides and screen promising new peptides identified through a peptide microarray approach. The goal...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1,196,355 Project Grant (CFDA 93.121 Oral Diseases and Disorders Research) to Regendodent, Inc. in Ann Arbor, Michigan. The grant will support the development of REGENDOGEL (RG), a new class of dental material that stimulates regeneration of dental pulp and dentin damaged by decay or trauma. The project aims to compare the original RG formulation using bovine-derived dentin matrix molecules (DMMs) with a new...