This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to investigate the role of the lysine-specific demethylase 1 (LSD1) enzyme in regulating osteoclast activity and bone loss during periodontal disease. The $236,756 award to the Regents of the University of Minnesota will fund a 2-year research project to gain mechanistic insights into how LSD1 deficiency affects osteoclast function and prevents bone loss in a ligature-induced periodontitis model. The research will utilize bulk RNA-seq, ATAC-seq, and single-cell sequencing techniques to examine skeletal site-specific changes in mandible-derived pre-osteoclasts and innate immune cell responses. The goal is to elucidate the epigenetic mechanisms by which LSD1 regulates inflammatory cytokine-induced osteoclast differentiation, with the potential to identify promising therapeutic targets for treating periodontal bone loss.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $236.8k | 4/8/25 |