This $515,926 Project Grant awarded by the National Science Foundation (NSF) Engineering program (CFDA 47.041) will fund research to develop an in vitro gingival (gum) tissue system to study the role of microbial communities on oral health and disease. The 5-year project, beginning June 1, 2024, will be conducted by the University of Massachusetts Lowell's Office of Research Administration-Lowell. The key objectives are: (1) developing and validating a microphysiological system to study oral...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $858,000 to the University of Texas Health Science Center at Houston to explore the mechanisms by which the bacterium Veillonella inhibits the hemolytic activity of Porphyromonas gingivalis, a key contributor to periodontal disease. The research aims to 1) investigate how Veillonella's heme production suppresses P....
This Project Grant award, funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop innovative strategies for periodontal tissue regeneration. The $456,500 award, spanning from June 1, 2025 to May 31, 2027, will support research to investigate the use of a peptide called leucine-rich amelogenin peptide (LRAP) in combination with self-assembling peptide amphiphile (PA) nanofibers to enhance...
This Project Grant award, valued at $675,684.00, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121). The funding will support research to investigate the microbial ecosystem around dental implants and understand the etiopathogenesis of peri-implantitis, a disease that can lead to implant failure. The research aims to create a functional atlas of the peri-implant sulcus, pinpoint...
This $429,000 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) supports research to study essential genes in the oral pathogen Fusobacterium nucleatum. The research aims to investigate the molecular basis for the essentiality of the FomA gene and systematically identify other essential genes in F. nucleatum. This work is intended to provide critical knowledge to develop targeted,...
This Project Grant award of $588,952 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop a bio-inspired scaffold (PeriopatchTM) for regenerating Sharpey's fibers and the periodontal ligament (PDL). The research, conducted by the University of Missouri System, focuses on integrating crucial biophysical and biochemical cues into a matrix to guide PDL stem cell migration, growth, and formation...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), aims to develop novel therapies for periodontal regeneration. The $1,705,144 award to the University of Pittsburgh will fund research to: 1) identify cell surface markers to isolate and characterize human periodontal ligament stem cells expressing the Prx1 transcription factor, 2) develop strategies to harness...
This $381,216 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to investigate the role of the ectonucleotidase CD73 in controlling inflammation and bone resorption in periodontal disease. The research aims to delineate how CD73 deficiency leads to metabolic dysfunction in gingival fibroblasts and its link to heightened osteoclast activity, as well as study how...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $995,000.00 to the ADA Forsyth Institute, Inc. (doing business as The Forsyth Institute) to conduct research on the mechanisms of peroxisome proliferator-activated receptor-alpha (PPAR-α) regulation in periodontitis. The research aims to determine if PPAR-α agonist treatment can modulate macrophage polarization to...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop a novel antibody-based therapy to prevent alveolar bone loss in severe periodontitis. The $304,019 award to Panorama Research Incorporated will fund the identification and evaluation of human anti-human OC-STAMP monoclonal antibodies, with the goal of identifying a lead candidate to potentially slow or halt...