This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will provide $381,216 to Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) from June 1, 2025 to March 31, 2030. The award will support research to investigate the role of the enzyme CD73 in regulating inflammation and bone loss associated with periodontal disease. Specifically, the project...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $446,875 to support research on the role of a novel G protein-coupled receptor, MRGPRX2, in the development of periodontal disease. The funded research aims to develop two humanized mouse models to study the contribution of MRGPRX2-expressing mast cells to Porphyromonas gingivalis-induced and ligature-induced...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $241,500 in funding to The Research Foundation For The State University Of New York to conduct research aimed at identifying diffusible small molecules that regulate the replication of the oral pathogen Porphyromonas gingivalis. The research will utilize chemical and molecular genetic strategies to elucidate the...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop novel therapies for endogenous periodontal regeneration. The $1,705,144 award to the University of Pittsburgh will fund research to: 1) identify specific cell surface markers to isolate and characterize human periodontal ligament stem cells expressing the PRX1 transcription factor (HPRX1-PCs); 2) develop a strategy...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $645,009 to the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to investigate the role of osteocyte nucleotide-binding oligomerization domain containing 1 (NOD1) in periodontal bone loss. The research aims to 1) determine if osteocytes use NOD1 to recognize periodontal pathogens...
This $431,750 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) supports research to decipher the mechanisms by which two proteins, AAFLP-1 and AADCUB, regulate the production of exopolysaccharide (PNAG) in the oral bacterium Aggregatibacter actinomycetemcomitans. The research aims to investigate how these two proteins, which are unique to A. actinomycetemcomitans, independently...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), focuses on understanding the role of CD4+ memory T cell subtypes in periodontal disease recurrence. The $248,999 award, with a project period from Apr 1, 2025 to Mar 31, 2030, aims to: Identify the spatiotemporal development of CD4+ memory T cells in periodontal tissues to determine their roles in the gingival immune landscape....
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $456,500.00 to the University of Southern California to conduct research on "Periodontal Regeneration with Supramolecular Nanomaterials". The goal is to investigate the use of a peptide called Leucine-rich Amelogenin Peptide (LRAP) and peptide amphiphile (PA) nanofibers to activate the Wnt/β-catenin...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $432,209 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to the University of California, Los Angeles (UCLA) for a 2-year period starting on August 1, 2023. The funding supports research to investigate the role of the CXCL10-CXCR3 axis in the compounding effects of diabetes mellitus on periodontitis. Specifically, the research aims to further elucidate the role of CXCL10 in the...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121), will support research to explore the role of T cell responses to the oral bacterium Aggregatibacter actinomycetemcomitans (AA) in the pathogenesis of periodontal disease. The total funding amount is $248,627 and the award period is from January 1, 2025 to December 31, 2029. The research will be conducted by the...