Project Grant R21DA064905
- Federal Grant Award Summary Louisiana State University Health Sciences Center New Orleans received a $225,065 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), effective August 15, 2025, with a completion date of July 31, 2027. The award supports research on targeting the renin system as a novel therapeutic approach for managing chronic pain and opioid use disorder (OUD). The project leverages the FDA-approved...
- Federal Grant Award Summary American University received a $476,496 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) beginning August 15, 2025, and concluding July 31, 2028. The grant funds fundamental neuroscience research investigating opioid signaling mechanisms in reward-guided decision-making within the rat prefrontal cortex, specifically the prelimbic area. The research employs a two-alternative forced choice...
- Federal Grant Award Summary Louisiana State University Health Sciences Center New Orleans received a $1.0125 million Project Grant from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), awarded September 5, 2025, with a completion date of May 31, 2030. The grant supports basic neuroscience research investigating the molecular mechanisms linking social stress to alcohol use disorder (AUD). Specifically, the research examines how...
- Federal Grant Award Summary Drexel University received a $832,132 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded on March 1, 2026, with a completion date of February 29, 2028. This research project investigates novel neurobiological mechanisms underlying opioid-induced dopamine elevation in the nucleus accumbens, advancing scientific understanding of opioid use disorder—a critical public health crisis....
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the Regents of the University of Minnesota a $673,724 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) effective May 1, 2026, through February 28, 2031. This research initiative will investigate how opioid exposure modifies nucleus accumbens microcircuits, with the ultimate goal of reversing or preventing maladaptive neuroplastic changes associated with opioid addiction. The project...
- Federal Grant Award Summary The University of Southern California received a $108,000 Project Grant from the National Institute on Drug Abuse under the Drug Use and Addiction Research Programs (CFDA 93.279) to support fundamental research investigating the molecular mechanisms of a kappa opioid receptor (KOR) selective negative allosteric modulator (NAM). The research, which commenced February 15, 2026, and concludes January 31, 2028, aims to elucidate the structural and functional basis of...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded The Medical University of South Carolina a Project Grant of $210,168 under the Drug Use and Addiction Research Programs (CFDA 93.279) for the period May 1, 2026, through April 30, 2028. This award supports basic neuroscience research investigating glutamatergic neural circuit mechanisms underlying opioid use disorder (OUD) and reward-seeking behavior. The funded research dissects pathway-specific glutamatergic...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded Oklahoma State University Center for Health Sciences a $377,586 Project Grant on February 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct research on sex-specific sumoylation mechanisms in heroin-seeking behavior. The research will examine how post-translational protein modifications mediated by the enzyme UBC9 influence heroin addiction and neuroadaptations differently in...
- Federal Project Grant Award Summary New York University has been awarded $201,250 by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) for a two-year project period from June 1, 2025, through May 31, 2027. This Project Grant supports basic neuroscience research investigating the synaptic organization of cholinergic interneurons in the nucleus accumbens, a brain region critical to motivated behaviors and implicated in substance use...
- Federal Grant Award Summary The University of South Carolina received a $192,149 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) beginning February 1, 2026, and concluding January 31, 2028. This research project investigates the noradrenergic mechanisms underlying stress-induced opioid reinstatement, addressing the neurobiological pathways connecting traumatic stress and comorbid conditions such as anxiety,...
Louisiana State University received a $409,587 Project Grant award from the National Institute on Drug Abuse under the Drug Use and Addiction Research Programs (CFDA 93.279), effective May 15, 2026 through April 30, 2028. The research project examines cell-type specific excitability and molecular mechanisms of opioid seeking, addressing a critical gap in understanding how opioid use induces neural adaptations that contribute to drug-seeking behavior and relapse in individuals with substance use disorders. The project delivers fundamental neuroscience research investigating changes in intrinsic excitability of medium spiny neurons in the nucleus accumbens across distinct neuronal populations, including dopamine D1 and D2 receptor-expressing cells as well as parvalbumin and choline acetyltransferase interneurons. The research specifically examines opioid-induced reductions in the sodium channel subunit SCN1B and their relationship to heroin-seeking behavior in self-administering animal models. This basic research aims to identify novel molecular mechanisms underlying opioid addiction, potentially informing the development of interventions to reduce relapse and opioid overdose deaths, which have quintupled over the past two decades and affect approximately one in ten individuals.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $409.6k | 5/11/26 |