Project Grant R01AA031733
- This federal Project Grant award of $396,643 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) supports research to elucidate the mechanisms underlying stress-potentiated ethanol drinking. The project aims to investigate the role of the histone methyltransferase G9a and its effects on dynorphin-positive neurons in the nucleus accumbens to regulate this behavior. Key objectives include testing the hypothesis that G9a's effects on...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $143,784 Project Grant (CFDA 93.273 - Alcohol Research Programs) to Louisiana State University Health Sciences Center New Orleans on July 30, 2024. The grant will support research to investigate the effects of adolescent opioid exposure on alcohol-induced hyperalgesia (increased pain sensitivity) in adult mice. The research aims to test the hypothesis that exposure to opioids during adolescence increases the magnitude of...
- This $156,204 Project Grant was awarded on May 15, 2025 by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) to the University of Massachusetts Medical School (UMMS) in Worcester, MA. The grant funding supports research on the role of protein kinase C delta (PKCδ)-expressing neurons in the bed nucleus of the stria terminalis (BNST) in compulsive ethanol intake behaviors. The research aims to utilize an operant conditioning task...
- This federal Project Grant award, funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), will support research on the role of somatostatin in the central amygdala in relation to heavy alcohol drinking. The research team at Boston University Medical Campus will use an animal model of heavy alcohol drinking, combined with pharmacological, molecular, and electrophysiological approaches, to test the hypothesis that activation of...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $571,673 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Mississippi Medical Center (UMMC). The funding supports research to investigate the combined behavioral effects of opioids and alcohol, and the potential role of a genetic variant of the mu opioid receptor (OPRM1 A118G) in influencing individual vulnerability to opioid-alcohol use and abuse. The research project will use rhesus...
- The Project Grant award of $657,156.00 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), supports research to examine the role of BK channels in alcohol-induced dysmyelination. The project aims to investigate the structural and functional correlates of myelin protein changes in a mouse model of alcohol use disorder, focusing on the effects of alcohol on oligodendrogenesis and pre-existing myelin. Key objectives include using...
- This federal Project Grant award of $2,552,568.00, awarded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) program, supports research to investigate the relationship between stress-induced neuroadaptations in the insula-BNST pathway and subsequent alcohol use disorder (AUD)-related behavior. The project, conducted by Wake Forest University Health Sciences, aims to elucidate how stress activation of AUD-associated...
- This federal Project Grant award for $700,000.00, issued by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program, supports research to investigate the neurophysiological and genetic factors contributing to binge drinking and alcohol use disorder. The primary awardee, the University of New Mexico (UNM) Health Sciences Center, will leverage techniques such as monosynaptic circuit labeling, optogenetics, electrophysiology,...
- This federal Project Grant award, provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), supports research to investigate the effects of chronic intermittent alcohol exposure on orbitofrontal cortex (OFC) astrocyte physiology, structure, and gene expression, and how these changes contribute to altered OFC neuron excitability and excessive drinking behaviors. The $459,707 award, with a period of performance from September 5,...
- This $232,316 Project Grant awarded by the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 - Alcohol Research Programs) supports research to investigate the role of a novel dynorphinergic circuit in the central amygdala and its connection to the nucleus accumbens. The research aims to understand how this circuit is modulated by chronic pain and fentanyl abstinence, and how it contributes to binge-like alcohol drinking behavior, pain-related cognitive effects, and reinstatement of...
This federal Project Grant award of $337,500.00, awarded on September 5, 2025 by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), supports a research project titled "Kappa Opioid Receptor Modulation of BLA Inputs to the BNST and Stress-Escalated Drinking" under the NIAAA's Alcohol Research Programs (CFDA 93.273). The project aims to investigate the neural mechanisms by which social stress leads to increased alcohol consumption, with a focus on the role of the kappa opioid receptor system in the basolateral amygdala (BLA) and its projections to the bed nucleus of the stria terminalis (BNST). The research, to be conducted by Louisiana State University Health Sciences Center New Orleans, will utilize novel mouse models and chemogenetic techniques to elucidate how the kappa opioid receptor system modulates the BLA-BNST pathway and influences stress-induced alcohol consumption. The ultimate goal is to inform the development of improved treatment and prevention strategies for alcohol use disorder.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $337.5k | 9/5/25 |